Queiroz Ciro Oliveira, Pitanga Francisco, Lotufo Paulo Andrade, Molina Maria Del Carmen Bisi, Aquino Estela Maria Leão de, Almeida Maria Conceição Chagas
MSc. Assistant Professor, Department of Physical Education, Escola Bahiana de Medicina e Saúde Pública (EBMSP), Salvador (BA), Brazil. Postgraduate Student, Postgraduate Program in Biotechnology in Health and Investigative Medicine, Centro de Pesquisa Gonçalo Muniz (CPqGM), Fundação Oswaldo Cruz (FIOCRUZ), Salvador (BA), Brazil.
PhD. Associate Professor, Department of Physical Education, Universidade Federal da Bahia (UFBA), Salvador (BA), Brazil.
Sao Paulo Med J. 2020 Jan-Feb;138(1):19-26. doi: 10.1590/1516-3180.2019.0301.R2.20102019.
Studies have shown that physical activity levels can be inversely associated with high-sensitivity C-reactive protein (hs-CRP) levels. However, the amount of physical activity required to maintain normal hs-CRP levels is still a matter for speculation.
To identify the amount of physical activity necessary to discriminate the hs-CRP levels in adults.
Cross-sectional study at six teaching and research institutions.
The study sample comprised 10,231 adults aged 35 to 74 years who were participants in the Brazilian Longitudinal Study of Adult Health (ELSA-Brasil). Receiver operating characteristic (ROC) curves were constructed to compare the amount of physical activity in two domains (leisure time and commuting) with hs-CRP levels. The sensitivity and specificity were calculated to identify the best cutoff for physical activity level that would be needed to maintain normal levels of hs-CRP (< 3 mg/l).
The area under the ROC curve was only statistically significant for discriminating normal levels of hs-CRP according to the amount of physical activity when the two study domains were added together. The accumulated physical activity level of 200 minutes/week was the best cutoff for discriminating normal levels of hs-CRP in adults of both sex.
Physical activity in the leisure-time and commuting domains together, of duration 200 minutes/week, was associated with normal hs-CRP values.
研究表明，身体活动水平可能与高敏C反应蛋白（hs-CRP）水平呈负相关。然而，维持正常hs-CRP水平所需的身体活动量仍有待推测。
确定区分成年人hs-CRP水平所需的身体活动量。
在六个教学和研究机构进行的横断面研究。
研究样本包括10231名年龄在35至74岁之间的成年人，他们是巴西成人健康纵向研究（ELSA-Brasil）的参与者。构建受试者工作特征（ROC）曲线，以比较两个领域（休闲时间和通勤）的身体活动量与hs-CRP水平。计算敏感性和特异性，以确定维持正常hs-CRP水平（<3mg/l）所需的身体活动水平的最佳临界值。
仅当将两个研究领域的身体活动量相加时，ROC曲线下面积在根据身体活动量区分正常hs-CRP水平方面才具有统计学意义。每周累计身体活动量200分钟是区分两性成年人正常hs-CRP水平的最佳临界值。
休闲时间和通勤领域的身体活动量加起来每周持续200分钟，与正常hs-CRP值相关。
