Ma Yunsheng, Griffith Jennifer A, Chasan-Taber Lisa, Olendzki Barbara C, Jackson Elizabeth, Stanek Edward J, Li Wenjun, Pagoto Sherry L, Hafner Andrea R, Ockene Ira S
Division of Preventive and Behavioral Medicine and the Division of Cardiovascular Medicine, University of Massachusetts Medical School, 55 Lake Avenue North, Worcester, MA 01655, USA.
Am J Clin Nutr. 2006 Apr;83(4):760-6. doi: 10.1093/ajcn/83.4.760.
High sensitivity C-reactive protein (CRP) is a marker of acute inflammation recently recognized as an independent predictor of future cardiovascular disease and diabetes. The identification of modifiable factors, such as diet, that influence serum CRP concentrations may provide the means for reducing the risk of these diseases. Data on longitudinal associations between dietary fiber intake and CRP are currently lacking.
The purpose of this study was to examine longitudinal associations between dietary fiber intake and CRP.
Data collection took place at baseline and quarterly (every 13 wk) thereafter for a total of 5 visits, each including measurements of body composition, CRP, diet, and physical activity. Relations between serum CRP and dietary fiber were assessed by using linear mixed models and logistic regression, adjusted for covariates.
A total of 524 subjects had multiple measurements of CRP and dietary factors. The average total dietary fiber intake was 16.11 g/d. Average serum CRP was 1.78 mg/L. We observed an inverse association between intake of total dietary fiber (separately for soluble and insoluble fiber) and CRP concentrations in both cross-sectional and longitudinal analyses. The likelihood of elevated CRP concentrations was 63% lower (OR: 0.37; 95% CI: 0.16, 0.87) in participants in the highest quartile of total fiber intake than in participants in the lowest quartile.
Our results suggest that dietary fiber is protective against high CRP, which supports current recommendations for a diet high in fiber.
高敏C反应蛋白（CRP）是一种急性炎症标志物，最近被认为是未来心血管疾病和糖尿病的独立预测指标。识别影响血清CRP浓度的可改变因素，如饮食，可能为降低这些疾病的风险提供方法。目前缺乏关于膳食纤维摄入量与CRP之间纵向关联的数据。
本研究的目的是检验膳食纤维摄入量与CRP之间的纵向关联。
在基线时以及此后每季度（每13周）进行一次数据收集，共进行5次访视，每次访视都包括身体成分、CRP、饮食和身体活动的测量。通过使用线性混合模型和逻辑回归评估血清CRP与膳食纤维之间的关系，并对协变量进行了调整。
共有524名受试者对CRP和饮食因素进行了多次测量。总膳食纤维平均摄入量为16.11克/天。血清CRP平均为1.78毫克/升。在横断面和纵向分析中，我们均观察到总膳食纤维摄入量（分别针对可溶性和不可溶性纤维）与CRP浓度之间呈负相关。总纤维摄入量最高四分位数的参与者中CRP浓度升高的可能性比最低四分位数的参与者低63%（比值比：0.37；95%置信区间：0.16，0.87）。
我们的结果表明膳食纤维对高CRP具有保护作用，这支持了当前对高纤维饮食的建议。
