Vester Birte
Dept. of Biochemistry and Molecular Biology, University of Southern Denmark, Denmark.
Res Microbiol. 2018 Feb-Mar;169(2):61-66. doi: 10.1016/j.resmic.2017.12.003. Epub 2018 Mar 2.
The Cfr methyl transferase causes an RNA methylation of the bacterial ribosomes impeding reduced or abolished binding of many antibiotics acting at the peptidyl transferase center. It provides multi-resistance to eight classes of antibiotics, most of which are in clinical and veterinary use. The cfr gene is found in various bacteria in many geographical locations and placed on plasmids or associated with transposons. Cfr-related genes providing similar resistance have been identified in Bacillales, and now also in the pathogens Clostridium difficile and Enterococcus faecium. In addition, the presence of the cfr gene has been detected in harbours and food markets.
Cfr甲基转移酶会导致细菌核糖体的RNA甲基化，从而阻碍许多作用于肽基转移酶中心的抗生素的结合，使其结合减少或完全丧失。它赋予对八类抗生素的多重耐药性，其中大多数抗生素都用于临床和兽医领域。cfr基因在许多地理位置的各种细菌中都能找到，它存在于质粒上或与转座子相关联。在芽孢杆菌目中已鉴定出提供类似耐药性的与Cfr相关的基因，现在在艰难梭菌和粪肠球菌等病原体中也发现了此类基因。此外，在港口和食品市场中也检测到了cfr基因的存在。
