Foxj1 表达的室管膜细胞不会为小鼠前脑损伤或中风部位提供新的细胞。
Foxj1 expressing ependymal cells do not contribute new cells to sites of injury or stroke in the mouse forebrain.
机构信息
WM Keck Center for Behavioral Biology, Program in Genetics, Program in Comparative Biomedical Sciences, Department of Molecular Biomedical Sciences, College of Veterinary Medicine, North Carolina State University,, 1060 William Moore Dr., Raleigh, NC, 27607, USA.
Department of Neurology, David Geffen School of Medicine, University of California, Los Angeles, 635 Charles Young Drive, CA, 90095, USA.
出版信息
Sci Rep. 2018 Jan 29;8(1):1766. doi: 10.1038/s41598-018-19913-x.
The stem cell source of neural and glial progenitors in the periventricular regions of the adult forebrain has remained uncertain and controversial. Using a cell specific genetic approach we rule out Foxj1+ ependymal cells as stem cells participating in neurogenesis and gliogenesis in response to acute injury or stroke in the mouse forebrain. Non stem- and progenitor-like responses of Foxj1+ ependymal cells to injury and stroke remain to be defined and investigated.
成体大脑前脑室周围区的神经和神经胶质前体细胞的干细胞来源一直存在争议。利用一种细胞特异性遗传方法，我们排除了 Foxj1+室管膜细胞作为干细胞，参与了急性损伤或中风后小鼠前脑的神经发生和神经胶质发生。Foxj1+室管膜细胞对损伤和中风的非干细胞和祖细胞样反应仍有待确定和研究。
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