• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

以及藻酸盐包裹的负载壳聚糖-磷酸钙的铁-牛乳铁蛋白纳米胶囊的抗念珠菌活性。

and anticandidal activities of alginate-enclosed chitosan-calcium phosphate-loaded Fe-bovine lactoferrin nanocapsules.

作者信息

Leng Khoo Miew, Vijayarathna Soundararajan, Jothy Subramanion L, Sasidharan Sreenivasan, Kanwar Jagat R

机构信息

Institute for Research in Molecular Medicine (INFORMM), Universiti Sains Malaysia, USM 11800, Pulau Pinang, Malaysia.

Nanomedicine-Laboratory of Immunology & Molecular Biomedical Research (LIMBR), School of Medicine (SoM), Faculty of Health, Deakin University, Waurn Ponds, Geelong, VIC 3217, Australia.

出版信息

Future Sci OA. 2017 Nov 16;4(2):FSO257. doi: 10.4155/fsoa-2017-0085. eCollection 2018 Feb.

DOI:10.4155/fsoa-2017-0085
PMID:29379633
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5778379/
Abstract

AIM

To study the and anticandidal activity of nanocapsulated bovine lactoferrin.

MATERIALS & METHODS: and antimicrobial activities were conducted to study the anticandidal activities of nanocapsules (NCs).

RESULTS

The NCs showed good anticandidal activities. The disruption of cell wall and cell membrane was noted via microscopy studies. The NCs changed the normal growth profile of . NCs reduced the colony forming unit in kidney and blood samples. Histopathological examination showed better cell structure and coordination compared with untreated mice kidney. NCs also enhanced the natural killing properties of by epithelial cells.

CONCLUSION

NCs have effective anticandidal properties and have the potential as a therapeutic agent against candidiasis.

摘要

目的

研究纳米胶囊化牛乳铁蛋白的抗念珠菌活性。

材料与方法

进行抗菌活性研究以探讨纳米胶囊（NCs）的抗念珠菌活性。

结果

NCs显示出良好的抗念珠菌活性。通过显微镜研究观察到细胞壁和细胞膜的破坏。NCs改变了白色念珠菌的正常生长模式。NCs降低了肾脏和血液样本中的菌落形成单位。组织病理学检查显示，与未治疗小鼠的肾脏相比，细胞结构和协调性更好。NCs还增强了上皮细胞对白色念珠菌的自然杀伤特性。

结论

NCs具有有效的抗念珠菌特性，有潜力作为治疗念珠菌病的药物。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7e5d/5778379/22e40cdb1f3a/fsoa-04-257-g7.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7e5d/5778379/1504e357c65f/fsoa-04-257-g1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7e5d/5778379/6eafc53830c8/fsoa-04-257-g2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7e5d/5778379/96cf65e5d8ff/fsoa-04-257-g3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7e5d/5778379/91e9cc1e1886/fsoa-04-257-g4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7e5d/5778379/0f95114862bb/fsoa-04-257-g5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7e5d/5778379/a340280616a8/fsoa-04-257-g6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7e5d/5778379/22e40cdb1f3a/fsoa-04-257-g7.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7e5d/5778379/1504e357c65f/fsoa-04-257-g1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7e5d/5778379/6eafc53830c8/fsoa-04-257-g2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7e5d/5778379/96cf65e5d8ff/fsoa-04-257-g3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7e5d/5778379/91e9cc1e1886/fsoa-04-257-g4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7e5d/5778379/0f95114862bb/fsoa-04-257-g5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7e5d/5778379/a340280616a8/fsoa-04-257-g6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7e5d/5778379/22e40cdb1f3a/fsoa-04-257-g7.jpg

相似文献

1
and anticandidal activities of alginate-enclosed chitosan-calcium phosphate-loaded Fe-bovine lactoferrin nanocapsules.以及藻酸盐包裹的负载壳聚糖-磷酸钙的铁-牛乳铁蛋白纳米胶囊的抗念珠菌活性。
Future Sci OA. 2017 Nov 16;4(2):FSO257. doi: 10.4155/fsoa-2017-0085. eCollection 2018 Feb.
2
In vitro and in vivo toxicity assessment of alginate/eudragit S 100-enclosed chitosan-calcium phosphate-loaded iron saturated bovine lactoferrin nanocapsules (Fe-bLf NCs).海藻酸钠/尤特奇 S100 包封壳聚糖-磷酸钙负载铁饱和牛乳铁蛋白纳米胶囊（Fe-bLf NCs）的体外和体内毒性评估。
Biomed Pharmacother. 2018 Jan;97:26-37. doi: 10.1016/j.biopha.2017.10.121. Epub 2017 Nov 6.
3
Novel alginate-enclosed chitosan-calcium phosphate-loaded iron-saturated bovine lactoferrin nanocarriers for oral delivery in colon cancer therapy.新型海藻酸钠包封的壳聚糖-磷酸钙负载铁饱和牛乳铁蛋白纳米载体用于结肠癌治疗的口服给药。
Nanomedicine (Lond). 2012 Oct;7(10):1521-50. doi: 10.2217/nnm.12.29. Epub 2012 Jun 26.
4
Oral administration of iron-saturated bovine lactoferrin-loaded ceramic nanocapsules for breast cancer therapy and influence on iron and calcium metabolism.口服铁饱和负载牛乳铁蛋白的陶瓷纳米胶囊用于乳腺癌治疗及其对铁和钙代谢的影响。
Int J Nanomedicine. 2015 Jun 22;10:4081-98. doi: 10.2147/IJN.S75877. eCollection 2015.
5
Fe-bLf nanoformulation targets survivin to kill colon cancer stem cells and maintains absorption of iron, calcium and zinc.铁-乳铁蛋白纳米制剂靶向survivin以杀死结肠癌干细胞，并维持铁、钙和锌的吸收。
Nanomedicine (Lond). 2015 Jan;10(1):35-55. doi: 10.2217/nnm.14.132. Epub 2014 Jul 14.
6
Oral administration of encapsulated bovine lactoferrin protein nanocapsules against intracellular parasite Toxoplasma gondii.口服包封的牛乳铁蛋白纳米胶囊对抗细胞内寄生虫刚地弓形虫。
Int J Nanomedicine. 2015 Oct 8;10:6355-69. doi: 10.2147/IJN.S85286. eCollection 2015.
7
Antiparasitic and immunomodulatory potential of oral nanocapsules encapsulated lactoferrin protein against Plasmodium berghei.口服纳米胶囊包被乳铁蛋白抗伯氏疟原虫的抗寄生虫和免疫调节潜力。
Nanomedicine (Lond). 2016 Jan;11(1):47-62. doi: 10.2217/nnm.15.181. Epub 2015 Dec 11.
8
Nanocapsules loaded with iron-saturated bovine lactoferrin have antimicrobial therapeutic potential and maintain calcium, zinc and iron metabolism.载铁饱和牛乳铁蛋白的纳米胶囊具有抗菌治疗潜力，并维持钙、锌和铁代谢。
Nanomedicine (Lond). 2015;10(8):1289-314. doi: 10.2217/nnm.14.209. Epub 2014 Dec 2.
9
LNA aptamer based multi-modal, Fe3O4-saturated lactoferrin (Fe3O4-bLf) nanocarriers for triple positive (EpCAM, CD133, CD44) colon tumor targeting and NIR, MRI and CT imaging.基于 LNA 适体的多模态、Fe3O4 饱和乳铁蛋白（Fe3O4-bLf）纳米载体，用于三阳性（EpCAM、CD133、CD44）结肠肿瘤靶向和近红外、磁共振成像和 CT 成像。
Biomaterials. 2015 Dec;71:84-99. doi: 10.1016/j.biomaterials.2015.07.055. Epub 2015 Aug 4.
10
In vitro, in situ and in vivo studies on the anticandidal activity of Cassia fistula seed extract.体外、原位和体内研究金腰子种子提取物的抗真菌活性。
Molecules. 2012 Jun 7;17(6):6997-7009. doi: 10.3390/molecules17066997.

引用本文的文献

1
Lactoferrin as a Versatile Agent in Nanoparticle Applications: From Therapeutics to Agriculture.乳铁蛋白作为纳米颗粒应用中的多功能剂：从治疗到农业。
Nanomaterials (Basel). 2024 Dec 16;14(24):2018. doi: 10.3390/nano14242018.

本文引用的文献

1
Antifungal Spectrum and Fungicidal Mechanism of an N-Terminal Peptide of Bovine Lactoferrin.牛乳铁蛋白N端肽的抗真菌谱及杀菌机制
J Infect Chemother. 1996;1(3):185-189. doi: 10.1007/BF02350646. Epub 2014 Apr 5.
2
Antifungal Mechanism of Action of Lactoferrin: Identification of H+-ATPase (P3A-Type) as a New Apoptotic-Cell Membrane Receptor.乳铁蛋白的抗真菌作用机制：鉴定H⁺-ATP酶（P3A类型）作为一种新的凋亡细胞膜受体。
Antimicrob Agents Chemother. 2016 Jun 20;60(7):4206-16. doi: 10.1128/AAC.03130-15. Print 2016 Jul.
3
Effects of bovine lactoferrin to oral Candida albicans and Candida glabrata isolates recovered from the saliva in elderly people.
牛乳铁蛋白对从老年人唾液中分离出的口腔白色念珠菌和光滑念珠菌的作用。
Odontology. 2015 Jan;103(1):50-5.
4
Analysis of the protein domain and domain architecture content in fungi and its application in the search of new antifungal targets.分析真菌中的蛋白质结构域和结构域体系内容及其在寻找新抗真菌靶点中的应用。
PLoS Comput Biol. 2014 Jul 17;10(7):e1003733. doi: 10.1371/journal.pcbi.1003733. eCollection 2014 Jul.
5
Fe-bLf nanoformulation targets survivin to kill colon cancer stem cells and maintains absorption of iron, calcium and zinc.铁-乳铁蛋白纳米制剂靶向survivin以杀死结肠癌干细胞，并维持铁、钙和锌的吸收。
Nanomedicine (Lond). 2015 Jan;10(1):35-55. doi: 10.2217/nnm.14.132. Epub 2014 Jul 14.
6
The role of nanomedicine in cell based therapeutics in cancer and inflammation.纳米医学在基于细胞的癌症和炎症治疗中的作用。
Int J Mol Cell Med. 2012 Summer;1(3):133-44.
7
The natural diyne-furan fatty acid EV-086 is an inhibitor of fungal delta-9 fatty acid desaturation with efficacy in a model of skin dermatophytosis.天然二炔基-呋喃脂肪酸 EV-086 是一种真菌 δ-9 脂肪酸去饱和酶的抑制剂，在皮肤真菌病模型中具有疗效。
Antimicrob Agents Chemother. 2014;58(1):455-66. doi: 10.1128/AAC.01443-13. Epub 2013 Nov 4.
8
A novel antimicrobial peptide derived from modified N-terminal domain of bovine lactoferrin: design, synthesis, activity against multidrug-resistant bacteria and Candida.一种源自牛乳铁蛋白修饰N端结构域的新型抗菌肽：设计、合成、对多重耐药菌和念珠菌的活性
Biochim Biophys Acta. 2013 Feb;1828(2):677-86. doi: 10.1016/j.bbamem.2012.09.021. Epub 2012 Sep 29.
9
Characterization of diverse antimicrobial peptides in skin secretions of Chungan torrent frog Amolops chunganensis.鉴定中华蟾蜍皮肤分泌物中多样化的抗菌肽。
Peptides. 2012 Nov;38(1):41-53. doi: 10.1016/j.peptides.2012.08.008. Epub 2012 Aug 19.
10
Novel alginate-enclosed chitosan-calcium phosphate-loaded iron-saturated bovine lactoferrin nanocarriers for oral delivery in colon cancer therapy.新型海藻酸钠包封的壳聚糖-磷酸钙负载铁饱和牛乳铁蛋白纳米载体用于结肠癌治疗的口服给药。
Nanomedicine (Lond). 2012 Oct;7(10):1521-50. doi: 10.2217/nnm.12.29. Epub 2012 Jun 26.