Christopoulou Eliza C, Filippatos Theodosios D, Elisaf Moses S
Department of Internal Medicine, School of Medicine, University of Ioannina, Ioannina, Greece.
Arch Med Sci Atheroscler Dis. 2017 Dec 31;2:e108-e112. doi: 10.5114/amsad.2017.72533. eCollection 2017.
The direct oral anticoagulant rivaroxaban is useful in various indications that include venous deep vein thrombosis prophylaxis/treatment after knee/hip replacement surgery and prevention of stroke in patients with non-valvular atrial fibrillation. Its mechanism of action has been mostly associated with hemorrhage-related adverse effects; thus a number of non-hemorrhage-related adverse effects of the drug have received less attention or go unrecognized. These adverse effects mainly include liver injury, hypersensitivity reactions, leukocytoclastic vasculitis and hair loss. Clinicians should be aware of these rare adverse reactions and advise their patients to contact them as soon as they observe any unexpected clinical response.
直接口服抗凝剂利伐沙班适用于多种适应症，包括膝关节/髋关节置换手术后静脉深静脉血栓形成的预防/治疗以及非瓣膜性心房颤动患者中风的预防。其作用机制主要与出血相关的不良反应有关；因此，该药物的一些非出血相关不良反应较少受到关注或未被认识到。这些不良反应主要包括肝损伤、过敏反应、白细胞破碎性血管炎和脱发。临床医生应了解这些罕见的不良反应，并建议患者一旦观察到任何意外的临床反应，立即与他们联系。
