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在肺血栓栓塞症治疗期间,利伐沙班和达比加群均引发白细胞破碎性血管炎的病例。

Case of both rivaroxaban- and dabigatran-induced leukocytoclastic vasculitis, during management of pulmonary thromboembolism.

作者信息

Lee Hong Lyeol, Kim Lucia, Kim Cheol Woo, Kim Jung Soo, Nam Hae Sung, Ryu Jeong Seon

机构信息

Department of Internal Medicine, Inha University College of Medicine, South Korea.

Department of Internal Pathology, Inha University College of Medicine, South Korea.

出版信息

Respir Med Case Rep. 2019 Jan 25;26:219-222. doi: 10.1016/j.rmcr.2019.01.017. eCollection 2019.

Abstract

Leukocytoclastic vasculitis is a disorder characterized by neutrophilic inflammation that is predominantly limited to the superficial cutaneous postcapillary venules. This condition may be idiopathic or may have a defined cause. Rivaroxaban and dabigatran have been widely used as warfarin alternatives, because of their efficacy and safety. In this case report, we describe a case of leukocytoclastic vasculitis induced by both rivaroxaban- and dabigatran-, which developed during the management of pulmonary thromboembolism.

摘要

白细胞破碎性血管炎是一种以中性粒细胞炎症为特征的疾病,主要局限于浅表皮肤毛细血管后微静脉。这种情况可能是特发性的,也可能有明确的病因。利伐沙班和达比加群因其有效性和安全性已被广泛用作华法林的替代药物。在本病例报告中,我们描述了一例在肺血栓栓塞症治疗期间由利伐沙班和达比加群共同诱发的白细胞破碎性血管炎病例。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e826/6356047/a4c77fea6796/gr1.jpg

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