Witchey Dexter Jordan, Witchey Nichole Brianne, Roth-Kauffman Michele Marie, Kauffman Mark Kevin
J Am Osteopath Assoc. 2018 Feb 1;118(2):92-105. doi: 10.7556/jaoa.2018.024.
Verrucae plantaris (plantar warts) are common cutaneous lesions of the plantar aspect of the foot that are caused by the human papillomavirus (HPV). Ubiquitous in our environment, asymptomatic infection with HPV occurs frequently, with most infections controlled or cleared by cellular and humoral immune responses. However, certain populations have been observed to manifest plantar warts at higher rates compared with the general population, placing them at increased risk for wart-induced pain and complications. Plantar warts shed HPV, which can then infect other sites in the plantar region or spread to other people. Although controlling risk factors is useful in preventing infection, the pervasive nature of HPV makes these preventive measures frequently impractical. This literature review outlines the current knowledge regarding the relationship between plantar wart pathophysiology, HPV transmission, and epidemiologic characteristics. Given the high propensity for treatment resistance of plantar warts and no established, practical, and reliable method of prevention, HPV prophylaxis for populations that demonstrate high rates of plantar warts may be of benefit in controlling the spread of lesions.
跖疣是由人乳头瘤病毒（HPV）引起的足部跖面常见皮肤病变。HPV在我们的环境中无处不在，无症状感染很常见，大多数感染通过细胞免疫和体液免疫反应得到控制或清除。然而，与普通人群相比，某些人群跖疣的发病率更高，这使他们患疣引起的疼痛和并发症的风险增加。跖疣会脱落HPV，然后可能感染跖区的其他部位或传播给其他人。虽然控制危险因素有助于预防感染，但HPV的普遍性使这些预防措施往往不切实际。这篇文献综述概述了目前关于跖疣病理生理学、HPV传播和流行病学特征之间关系的知识。鉴于跖疣具有高度的治疗抵抗性，且没有既定的、实用且可靠的预防方法，对跖疣发病率高的人群进行HPV预防可能有助于控制病变的传播。
