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手术与保守治疗跖疣的疗效比较:一项队列研究

Efficacy of Surgical vs. Conservative Treatment in HPV Plantar Warts: A Cohort Study.

作者信息

Miralles María José Chiva, Igual Jose Maria Blasco, Romero Cecili Macián, Sales Enrique Sanchis, Gomariz Carmen García, Vallés Adrián Jorda

机构信息

Department of Nursing University of Valencia Valencia Spain.

Department of Physiotherapy University of Valencia Valencia Spain.

出版信息

Health Sci Rep. 2025 Apr 29;8(5):e70776. doi: 10.1002/hsr2.70776. eCollection 2025 May.

DOI:10.1002/hsr2.70776
PMID:40309646
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12040750/
Abstract

BACKGROUND AND AIM

Plantar warts are a high reason for consultation in our daily clinic. There are multiple and varied treatments to eliminate this viral tumor in the foot, although each treatment also presents different results and effectiveness. The goal was to compare the efficacy of surgical treatment vs. conservative treatment of plantar warts, in aspects such as treatment time and number of cures.

METHODS

This was a cohort study with a sample of 72 lesions ( = 72). The effectiveness of plantar wart surgery was evaluated and compared to conservative treatments (nitric acid, bleomycin, and a combination of both). Conservative treatments were applied once a week until complete healing. The surgical removal of the wart and its closure was a secondary intention.

RESULTS

Overall, 30% of the injuries were treated surgically and the rest conservatively. The clinical resolution varied between 4 and 393 days, with a mean of 51.8 (SD 65.9) days. Conservative treatment times increase by 1.9 days compared to the surgical recovery time, which on a practical level means 21.9 days compared to 70.1 days.

CONCLUSION

The excision of the plantar wart reduces the duration of the treatment by around 50% compared to conservative treatments; these findings could be considered in clinical practice when choosing a treatment.

摘要

背景与目的

跖疣是我们日常门诊中患者前来咨询的一个重要原因。虽然有多种不同的治疗方法来消除足部的这种病毒性肿物,但每种治疗方法的效果和有效性也各不相同。本研究的目的是比较手术治疗与保守治疗跖疣在治疗时间和治愈次数等方面的疗效。

方法

这是一项队列研究,样本为72个病灶(n = 72)。评估了跖疣手术治疗的有效性,并与保守治疗(硝酸、博来霉素以及两者联合)进行比较。保守治疗每周进行一次,直至完全愈合。疣的手术切除及其闭合为二期愈合。

结果

总体而言,30%的病灶接受了手术治疗,其余采用保守治疗。临床治愈时间在4至393天之间,平均为51.8天(标准差65.9)。与手术恢复时间相比,保守治疗时间延长了1.9天,实际而言,保守治疗时间为70.1天,手术恢复时间为21.9天。

结论

与保守治疗相比,跖疣切除术可使治疗时间缩短约50%;在临床实践中选择治疗方法时可参考这些研究结果。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e63f/12040750/a63267d2e67f/HSR2-8-e70776-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e63f/12040750/25fd72736b7d/HSR2-8-e70776-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e63f/12040750/ed82105ea751/HSR2-8-e70776-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e63f/12040750/a15a3e29e323/HSR2-8-e70776-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e63f/12040750/10bf280f14c4/HSR2-8-e70776-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e63f/12040750/a63267d2e67f/HSR2-8-e70776-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e63f/12040750/25fd72736b7d/HSR2-8-e70776-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e63f/12040750/ed82105ea751/HSR2-8-e70776-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e63f/12040750/a15a3e29e323/HSR2-8-e70776-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e63f/12040750/10bf280f14c4/HSR2-8-e70776-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e63f/12040750/a63267d2e67f/HSR2-8-e70776-g005.jpg

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本文引用的文献

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Emerging Intralesional Treatments for Plantar Warts: A Systematic Review.足底疣的新兴局部治疗方法:系统评价。
J Drugs Dermatol. 2022 Dec 1;21(12):1322-1329. doi: 10.36849/JDD.6735.
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Clinical guideline for the diagnosis and treatment of cutaneous warts (2022).临床皮肤疣病诊断与治疗指南(2022)。
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A non-invasive method for diagnosing plantar warts caused by human papillomavirus (HPV).一种用于诊断由人乳头瘤病毒(HPV)引起的足底疣的非侵入性方法。
J Med Virol. 2022 Jun;94(6):2897-2901. doi: 10.1002/jmv.27514. Epub 2021 Dec 15.
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The status of treatment for plantar warts in 2021: No definitive advancements in decades for a common dermatology disease.2021 年足底疣治疗现状:一种常见皮肤病数十年来仍无明确疗法。
Clin Dermatol. 2021 Jul-Aug;39(4):688-694. doi: 10.1016/j.clindermatol.2021.05.024. Epub 2021 May 19.
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Diagnostic techniques in HPV infections and the need to implement them in plantar lesions: A systematic review.HPV 感染的诊断技术以及在足底病变中应用这些技术的必要性:系统评价。
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Topical treatment for plantar warts: A systematic review.足底疣的局部治疗:系统评价。
Dermatol Ther. 2021 Jan;34(1):e14621. doi: 10.1111/dth.14621. Epub 2020 Dec 14.
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Plantar Warts: Epidemiology, Pathophysiology, and Clinical Management.跖疣:流行病学、病理生理学及临床管理
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A retrospective audit of lesion excision and rotation skin flap for the treatment of intractable plantar keratosis.回顾性分析病灶切除联合旋转皮瓣治疗顽固性足底角化病的疗效。
Foot (Edinb). 2018 Mar;34:23-27. doi: 10.1016/j.foot.2017.09.004. Epub 2017 Sep 28.
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Human papillomaviruses genotyping in plantar warts.人乳头瘤病毒在足底疣中的基因分型。
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