Universidade Federal de São Paulo. Escola Paulista de Medicina. Departamento de Fisiologia, São Paulo (SP), Brazil.
Laboratory of Multidisciplinary Research, Universidade São Francisco, São Paulo, Brazil.
Sci Rep. 2018 Jan 30;8(1):1869. doi: 10.1038/s41598-018-20174-x.
The objective was to investigate the effects of the maternal consumption of the green tea extract during pregnancy and lactation on mothers and offspring metabolism. The female Wistar rats, on the first day of pregnancy until the end of lactation, was divided into groups: MC- received water and ME- received green tea extract (400 mg/kg body weight/day), both ingested control diet. After lactation, at day 28 post-partum, the mothers and pups from each mother were euthanized and composed the groups: FC- pup from mother received water and FE- pup from mother received green tea extract. The ME group increased IL-10/TNF-α ratio and IL-1β content in the mesenteric and IL-1β content in retroperitoneal adipose tissues, and decreased catalase activity. The FE group decreased the retroperitoneal adipose tissue relative weight and SOD activity, but increased adiponectin, LPS, IL-10 and IL-6 content and IL-10/TNF-α ratio in retroperitoneal, IL-10 and TNF-α content in gonadal, and IL-6 content in mesenteric adipose tissues. In summary, the maternal consumption of green tea extract associated with control diet ingestion during pregnancy and lactation altered the inflammatory status of mothers and 28d-old offspring. These data elucidate the effects of green tea during pregnancy and lactation on maternal and offspring metabolism.
目的是研究母亲在妊娠和哺乳期摄入绿茶提取物对母亲和后代代谢的影响。雌性 Wistar 大鼠从妊娠第一天到哺乳期结束，分为两组：MC- 给予水，ME- 给予绿茶提取物（400mg/kg 体重/天），均摄入对照饮食。哺乳期结束后，产后第 28 天，每组处死母鼠及其幼崽，并分为 FC- 来自母亲接受水的幼崽和 FE- 来自母亲接受绿茶提取物的幼崽。ME 组增加了肠系膜和腹膜后脂肪组织中的 IL-10/TNF-α 比值和 IL-1β 含量，并降低了过氧化氢酶活性。FE 组降低了腹膜后脂肪组织的相对重量和 SOD 活性，但增加了脂联素、LPS、IL-10 和 IL-6 含量以及腹膜后、性腺中的 IL-10 和 TNF-α 含量，肠系膜脂肪组织中的 IL-6 含量。总之，母亲在妊娠和哺乳期摄入绿茶提取物并同时摄入对照饮食会改变母亲和 28 日龄幼崽的炎症状态。这些数据阐明了绿茶在妊娠和哺乳期对母婴代谢的影响。
