Udhayarasu Madhanlal, Ramakrishnan Kalpana, Periasamy Soundararajan
Department of Biomedical Engineering, Rajalakshmi Engineering College, Chennai, India.
Department of Nephrology, Sri Ramachandra University, Chennai, India.
Healthc Technol Lett. 2017 May 23;4(6):223-227. doi: 10.1049/htl.2016.0098. eCollection 2017 Dec.
Periodical monitoring of renal function, specifically for subjects with history of diabetic or hypertension would prevent them from entering into chronic kidney disease (CKD) condition. The recent increase in numbers may be due to food habits or lack of physical exercise, necessitates a rapid kidney function monitoring system. Presently, it is determined by evaluating glomerular filtration rate (GFR) that is mainly dependent on serum creatinine value and demographic parameters and ethnic value. Attempted here is to develop ethnic parameter based on skin texture for every individual. This value when used in GFR computation, the results are much agreeable with GFR obtained through standard modification of diet in renal disease and CKD epidemiology collaboration equations. Once correlation between CKD and skin texture is established, classification tool using artificial neural network is built to categorise CKD level based on demographic values and parameter obtained through skin texture (without using creatinine). This network when tested gives almost at par results with the network that is trained with demographic and creatinine values. The results of this Letter demonstrate the possibility of non-invasively determining kidney function and hence for making a device that would readily assess the kidney function even at home.
定期监测肾功能,特别是对于有糖尿病或高血压病史的受试者,可防止他们进入慢性肾脏病(CKD)状态。近期病例数的增加可能归因于饮食习惯或缺乏体育锻炼,因此需要一个快速的肾功能监测系统。目前,通过评估主要依赖血清肌酐值、人口统计学参数和种族值的肾小球滤过率(GFR)来确定肾功能。本文尝试为每个人开发基于皮肤纹理的种族参数。将该值用于GFR计算时,结果与通过肾病饮食标准修正和CKD流行病学协作方程获得的GFR非常吻合。一旦建立了CKD与皮肤纹理之间的相关性,就构建使用人工神经网络的分类工具,根据人口统计学值和通过皮肤纹理获得的参数(不使用肌酐)对CKD水平进行分类。对该网络进行测试时,其结果与使用人口统计学和肌酐值训练的网络几乎相当。本信函的结果表明了非侵入性测定肾功能的可能性,从而有可能制造出一种即使在家中也能方便地评估肾功能的设备。