G2S：一个用于在 3D 蛋白质结构上注释基因组变异的网络服务。
G2S: a web-service for annotating genomic variants on 3D protein structures.
机构信息
Department of Electrical Engineering & Computer Science and Christopher S. Bond Life Sciences Center, University of Missouri, Columbia, MO 65211, USA.
Kravis Center for Molecular Oncology, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.
出版信息
Bioinformatics. 2018 Jun 1;34(11):1949-1950. doi: 10.1093/bioinformatics/bty047.
MOTIVATION
Accurately mapping and annotating genomic locations on 3D protein structures is a key step in structure-based analysis of genomic variants detected by recent large-scale sequencing efforts. There are several mapping resources currently available, but none of them provides a web API (Application Programming Interface) that supports programmatic access.
RESULTS
We present G2S, a real-time web API that provides automated mapping of genomic variants on 3D protein structures. G2S can align genomic locations of variants, protein locations, or protein sequences to protein structures and retrieve the mapped residues from structures. G2S API uses REST-inspired design and it can be used by various clients such as web browsers, command terminals, programming languages and other bioinformatics tools for bringing 3D structures into genomic variant analysis.
AVAILABILITY AND IMPLEMENTATION
The webserver and source codes are freely available at https://g2s.genomenexus.org.
CONTACT
SUPPLEMENTARY INFORMATION
Supplementary data are available at Bioinformatics online.
动机
准确地将基因组位置映射和注释到 3D 蛋白质结构上，是对最近大规模测序工作中检测到的基因组变异进行基于结构的分析的关键步骤。目前有几个映射资源，但没有一个提供支持编程访问的实时 Web API（应用程序编程接口）。
结果
我们提出了 G2S，这是一个实时的 Web API，提供了对 3D 蛋白质结构上基因组变异的自动映射。G2S 可以将变异、蛋白质位置或蛋白质序列的基因组位置映射到蛋白质结构，并从结构中检索映射的残基。G2S API 采用了基于 REST 的设计，可以被各种客户端（如网络浏览器、命令终端、编程语言和其他生物信息学工具）使用，将 3D 结构引入到基因组变异分析中。
可用性和实现
该 Web 服务器和源代码可在 https://g2s.genomenexus.org 上免费获得。
联系信息
补充信息
补充数据可在 Bioinformatics 在线获得。
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