TOXsIgN：用于毒基因组特征的跨物种存储库。
TOXsIgN: a cross-species repository for toxicogenomic signatures.
机构信息
Univ Rennes, Inserm, EHESP, Irset (Institut de recherche en santé, environnement et travail) - UMR_S1085, F-35000 Rennes, France.
Institut de Recherche en Informatique et Systèmes Aléatoires (IRISA/INRIA) - GenOuest Platform, Université de Rennes 1, F-35042 Rennes, France.
出版信息
Bioinformatics. 2018 Jun 15;34(12):2116-2122. doi: 10.1093/bioinformatics/bty040.
MOTIVATION
At the same time that toxicologists express increasing concern about reproducibility in this field, the development of dedicated databases has already smoothed the path toward improving the storage and exchange of raw toxicogenomic data. Nevertheless, none provides access to analyzed and interpreted data as originally reported in scientific publications. Given the increasing demand for access to this information, we developed TOXsIgN, a repository for TOXicogenomic sIgNatures.
RESULTS
The TOXsIgN repository provides a flexible environment that facilitates online submission, storage and retrieval of toxicogenomic signatures by the scientific community. It currently hosts 754 projects that describe more than 450 distinct chemicals and their 8491 associated signatures. It also provides users with a working environment containing a powerful search engine as well as bioinformatics/biostatistics modules that enable signature comparisons or enrichment analyses.
AVAILABILITY AND IMPLEMENTATION
The TOXsIgN repository is freely accessible at http://toxsign.genouest.org. Website implemented in Python, JavaScript and MongoDB, with all major browsers supported.
SUPPLEMENTARY INFORMATION
Supplementary data are available at Bioinformatics online.
动机
在毒理学家对该领域的可重复性表示越来越多的关注的同时，专门的数据库的发展已经为改善毒理基因组学原始数据的存储和交换铺平了道路。然而，没有一个数据库提供对原始科学出版物中报告的分析和解释后的数据的访问。鉴于对访问这些信息的需求不断增加，我们开发了 TOXsIgN，这是一个用于存储毒理基因组学特征的存储库。
结果
TOXsIgN 存储库提供了一个灵活的环境，便于毒理基因组学特征由科学界在线提交、存储和检索。它目前拥有 754 个项目，描述了 450 多种不同的化学物质及其 8491 个相关特征。它还为用户提供了一个工作环境，其中包含一个强大的搜索引擎以及生物信息学/生物统计学模块，可用于特征比较或富集分析。
可用性和实现
TOXsIgN 存储库可在 http://toxsign.genouest.org 免费访问。网站使用 Python、JavaScript 和 MongoDB 实现，支持所有主流浏览器。
补充信息
补充数据可在 Bioinformatics 在线获取。
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