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基因组转化的社会和行为科学优先事项。

Social and behavioral science priorities for genomic translation.

机构信息

Social and Behavioral Research Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD, USA.

Office of Behavioral and Social Sciences Research, Office of the Director, National Institutes of Health, Bethesda, MD, USA.

出版信息

Transl Behav Med. 2018 Jan 29;8(1):137-143. doi: 10.1093/tbm/ibx052.

Abstract

This commentary highlights the essential role of the social and behavioral sciences for genomic translation, and discusses some priority research areas in this regard. The first area encompasses genetics of behavioral, social, and neurocognitive factors, and how integration of these relationships might impact the development of treatments and interventions. The second area includes the contributions that social and behavioral sciences make toward the informed translation of genomic developments. Further, there is a need for behavioral and social sciences to inform biomedical research for effective implementation. The third area speaks to the need for increased outreach and education efforts to improve the public's genomic literacy such that individuals and communities can make informed health-related and societal (e.g., in legal or consumer settings) decisions. Finally, there is a need to prioritize representation of diverse communities in genomics research and equity of access to genomic technologies. Examples from National Institutes of Health-based intramural and extramural research programs and initiatives are used to discuss these points.

摘要

本评论强调了社会和行为科学对于基因组转化的重要作用,并讨论了这方面的一些优先研究领域。第一个领域包括行为、社会和神经认知因素的遗传学,以及这些关系的整合如何可能影响治疗和干预措施的发展。第二个领域包括社会和行为科学对基因组发展的知情转化的贡献。此外,行为和社会科学需要为生物医学研究提供信息,以实现有效实施。第三个领域涉及需要加强外展和教育工作,以提高公众的基因组素养,使个人和社区能够做出明智的与健康相关的和社会相关的(例如,在法律或消费者环境中)决策。最后,需要优先考虑在基因组研究中代表不同社区,并确保公平获得基因组技术。使用来自美国国立卫生研究院(National Institutes of Health)内部和外部研究计划和倡议的例子来讨论这些要点。

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