姜黄素类似物 CH-5 抑制人胃癌细胞系 HGC-27 的增殖、迁移和侵袭。
Curcumin Analog CH-5 Suppresses the Proliferation, Migration, and Invasion of the Human Gastric Cancer Cell Line HGC-27.
机构信息
Biotechnology Unit, University of Ribeirão Preto, Av. Costábile Romano, 2201, Ribeirão Preto, SP CEP 14096-900, Brazil.
Medicine School, University of Ribeirão Preto, Av. Costábile Romano, 2201, Ribeirão Preto, SP CEP 14096-900, Brazil.
出版信息
Molecules. 2018 Jan 30;23(2):279. doi: 10.3390/molecules23020279.
Gastric cancer is one of the most frequent malignant tumors in the world. The majority of patients are diagnosed with metastatic gastric cancer, which has a low survival rate. These data reinforce the importance of studying the anticancer activity of new molecules with the potential to suppress gastric cancer metastasis. Curcumin is a well-studied compound that has demonstrated anti-metastatic effects. Here we investigated if CH-5, a curcumin derivative compound, has anti-metastatic properties in the human gastric cancer cell line HGC-27. Firstly, we found that CH-5 decreased viability and induced apoptosis in HGC-27 cells in a dose-dependent manner. Additionally, CH-5 suppressed the migration and invasion of HGC-27 cells by downregulating the expression and collagenase activity of matrix metalloproteinase 2 in a dose-dependent manner. In conclusion, CH-5 showed anticancer activities, including the induction of apoptosis, and the suppression of migration and invasion in HGC-27 cells, suggesting that CH-5 can be a lead molecule for the development of anti-metastatic drugs for gastric cancer therapy.
胃癌是世界上最常见的恶性肿瘤之一。大多数患者被诊断为转移性胃癌，其生存率较低。这些数据强调了研究具有抑制胃癌转移潜力的新分子抗癌活性的重要性。姜黄素是一种研究得很好的化合物，已显示出抗转移作用。在这里，我们研究了姜黄素衍生物化合物 CH-5 是否对人胃癌细胞系 HGC-27 具有抗转移特性。首先，我们发现 CH-5 以剂量依赖性方式降低 HGC-27 细胞的活力并诱导其凋亡。此外，CH-5 通过下调基质金属蛋白酶 2 的表达和胶原酶活性，以剂量依赖性方式抑制 HGC-27 细胞的迁移和侵袭。总之，CH-5 表现出抗癌活性，包括诱导凋亡以及抑制 HGC-27 细胞的迁移和侵袭，表明 CH-5 可以成为开发用于胃癌治疗的抗转移药物的先导分子。
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