Liu Wei-Lun, Chang Jia-Ming, Chong Inn-Wen, Hung Yi-Li, Chen Yung-Hsiang, Huang Wen-Tsung, Kuo Hsuan-Fu, Hsieh Chong-Chao, Liu Po-Len
Department of Intensive Care Medicine, Chi Mei Medical Center, Liouying, Tainan 73657, Taiwan.
School of Medicine, College of Medicine, Fu Jen Catholic University, New Taipei 24205, Taiwan.
Molecules. 2017 Jun 3;22(6):929. doi: 10.3390/molecules22060929.
Metastasis is common in lung cancer and is associated with poor clinical outcomes and increased mortality. Curcumin is a natural anti-cancer agent that inhibits the metastasis of various cancers by modulating the expression of micro (mi) RNAs such as miR-98, which acts as a tumor suppressor. This study investigated the effect of curcumin on miR-98 expression and in vitro cell line growth and invasiveness in lung cancer. Curcumin treatment enhanced the expression of miR-98 and reduced that of the miR-98 target gene as well as () and in vitro and in vivo. MiR-98 overexpression suppressed lung cancer cell migration and invasion by inhibiting LIN28A-induced MMP2 and MMP9 expression. Meanwhile, level was downregulated by overexpression of miR-98 mimic. Induction of miR-98 by curcumin treatment suppressed MMP2 and MMP9 by targeting LIN28A. These findings provide insight into the mechanisms by which curcumin suppresses lung cancer cell line growth in vitro and in vivo and invasiveness in vitro.
转移在肺癌中很常见，与不良临床结果及死亡率增加相关。姜黄素是一种天然抗癌剂，可通过调节微小（mi）RNA如作为肿瘤抑制因子的miR-98的表达来抑制各种癌症的转移。本研究调查了姜黄素对肺癌中miR-98表达以及体外细胞系生长和侵袭性的影响。姜黄素处理增强了miR-98的表达，并在体外和体内降低了miR-98靶基因以及（）和（）的表达。miR-98过表达通过抑制LIN28A诱导的MMP2和MMP9表达来抑制肺癌细胞迁移和侵袭。同时，miR-98模拟物过表达使（）水平下调。姜黄素处理诱导miR-98通过靶向LIN28A抑制MMP2和MMP9。这些发现为姜黄素在体外和体内抑制肺癌细胞系生长以及体外侵袭性的机制提供了见解。
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