National Research Council, Neuroscience Institute, Aging Branch, Padova, Italy.
Ambulatory of Nutrition, IRCCS "S. de Bellis", National Institute of Gastroenterology-Research Hospital, Castellana Grotte, Bari, Italy.
Eur J Clin Nutr. 2018 Apr;72(4):587-592. doi: 10.1038/s41430-018-0097-y. Epub 2018 Jan 31.
BACKGROUND/OBJECTIVES: A small number of case-control studies have suggested that mitochondrial haplogroups could be associated with obesity. We examined whether obesity risk was influenced by mitochondrial haplogroup in a large North American cohort across an 8-year period. We conducted a longitudinal cohort study including individuals from the Osteoarthritis Initiative.
SUBJECTS/METHODS: Mitochondrial haplogroups were determined by sequencing and PCR-RFLP techniques using this nomenclature: HV, JT, KU, IWX, and super HV/others. The strength of the association between mitochondrial haplogroups and incident obesity was quantified with hazard ratios (HRs), adjusted for potential confounders using a Cox's regression analysis.
Overall, 2342 non-obese Caucasian participants (56.7% women) with a mean ± SD age of 62.0 ± 9.5 years at baseline were included. During a median follow-up of 8 years, 334 individuals ( = 14.3% of baseline population) became obese. After adjusting for nine potential confounders, the haplogroups IWX carried a significant 48% higher risk of obesity (HR = 1.48; 95% CI: 1.02-2.39) compared to the HV haplotype (the most frequent type).
Only the presence of the IWX haplogroups appears to be linked to increased obesity risk, independent of potential baseline confounders. Future cohort studies are needed to confirm these findings and to determine potential underlying mechanisms.
背景/目的：少数病例对照研究表明，线粒体单倍群可能与肥胖有关。我们研究了在一个跨越 8 年的大型北美队列中，线粒体单倍群是否会影响肥胖风险。我们进行了一项纵向队列研究，其中包括来自骨关节炎倡议的个体。
使用以下命名法通过测序和 PCR-RFLP 技术确定线粒体单倍群：HV、JT、KU、IWX 和超级 HV/其他。使用 Cox 回归分析调整潜在混杂因素后，用风险比 (HR) 量化线粒体单倍群与新发肥胖之间的关联强度。
总体而言，共有 2342 名非肥胖白种人参与者（56.7%为女性），基线时的平均年龄 ± 9.5 岁，中位数随访 8 年期间，有 334 人（ = 基线人群的 14.3%）肥胖。在调整了九个潜在混杂因素后，与 HV 单倍型相比，IWX 单倍群肥胖的风险显著增加了 48%（HR = 1.48；95%CI：1.02-2.39）。
只有 IWX 单倍群的存在似乎与肥胖风险增加有关，独立于潜在的基线混杂因素。需要进一步的队列研究来证实这些发现，并确定潜在的潜在机制。
