Naguib M, Gyasi H K, Abdulatif M, Absood G H
Can Anaesth Soc J. 1986 Mar;33(2):150-6. doi: 10.1007/BF03010824.
To determine the optimal interval between the administration of the priming dose and the intubating dose, atracurium was given to 44 patients either in a single dose of 0.5 mg X kg-1 or in an initial dose of 0.06 mg X kg-1 followed two, three or five minutes later with 0.44 mg X kg-1. When atracurium was given as a single bolus of 0.5 mg X kg-1 the time to 100 per cent twitch suppression (onset time) was 90.9 +/- 36 (mean +/- SD) seconds. When the priming interval was two minutes, the onset time of the intubating dose was 76.6 +/- 42.2 seconds (p = NS). But when the priming interval was three or five minutes, the onset times were 42.2 +/- 16.5 (p less than 0.01) and 52.6 +/- 28.8 (p less than 0.05) seconds respectively. Waiting for five minutes after the administration of the priming dose did not improve the intubating conditions. It is concluded that three minutes appears to be the optimal time interval for the administration of atracurium in divided doses. When a priming dose of atracurium is given three minutes before the intubating dose, it can provide an alternative to succinylcholine for rapid endotracheal intubation.
为确定预注剂量与插管剂量之间的最佳间隔时间，对44例患者给予阿曲库铵，给药方式为：单次给予0.5mg/kg，或先给予初始剂量0.06mg/kg，然后在2、3或5分钟后再给予0.44mg/kg。当以单次推注0.5mg/kg给予阿曲库铵时，达到100%颤搐抑制的时间（起效时间）为90.9±36（均值±标准差）秒。当预注间隔为2分钟时，插管剂量的起效时间为76.6±42.2秒（p=无显著性差异）。但当预注间隔为3分钟或5分钟时，起效时间分别为42.2±16.5秒（p<0.01）和52.6±28.8秒（p<0.05）。预注剂量给药后等待5分钟并未改善插管条件。得出结论：对于分次给予阿曲库铵，3分钟似乎是最佳时间间隔。当在插管剂量前3分钟给予阿曲库铵预注剂量时，它可为快速气管内插管提供琥珀酰胆碱的替代方法。
