用于导电、可生物降解支架的电纺苯胺四聚体-聚己内酯纤维
Electrospun aniline-tetramer--polycaprolactone fibres for conductive, biodegradable scaffolds.
作者信息
Guex A G, Spicer C D, Armgarth A, Gelmi A, Humphrey E J, Terracciano C M, Harding S, Stevens M M
机构信息
Department of Materials, Department of Bioengineering, and Institute of Biomedical Engineering, Imperial College London, Prince Consort Road, London SW7 2AZ, UK.
National Heart and Lung Institute, Imperial College London, Du Cane Road, London W12 0NN, UK.
出版信息
MRS Commun. 2017 Sep;7(3):375-382. doi: 10.1557/mrc.2017.45. Epub 2017 Jul 10.
Conjugated polymers have been proposed as promising materials for scaffolds in tissue engineering applications. The restricted processability and biodegradability of conjugated polymers limit their use for biomedical applications however. Here we synthesised a block--polymer of aniline tetramer and PCL (AT-PCL), and processed it into fibrous non-woven scaffolds by electrospinning. We showed that fibronectin (Fn) adhesion was dependant on the AT-PCL oxidative state, with a reduced Fn unfolding length on doped membranes. Furthermore, we demonstrated the cytocompatibility and potential of these membranes to support the growth and osteogenic differentiation of MC3T3-E1 over 21 days.
共轭聚合物已被认为是用于组织工程应用支架的有前途的材料。然而，共轭聚合物有限的可加工性和生物降解性限制了它们在生物医学应用中的使用。在这里，我们合成了苯胺四聚体和聚己内酯（AT-PCL）的嵌段聚合物，并通过静电纺丝将其加工成纤维状非织造支架。我们表明，纤连蛋白（Fn）的粘附取决于AT-PCL的氧化状态，掺杂膜上的Fn展开长度会减小。此外，我们证明了这些膜在21天内支持MC3T3-E1细胞生长和成骨分化的细胞相容性和潜力。
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