银屑病与代谢综合征的关联及风险。
Links and risks associated with psoriasis and metabolic syndrome.
作者信息
Liakou Aikaterini I, Zouboulis Christos C
机构信息
Departments of Dermatology, Venereology, Allergology and Immunology, Dessau Medical Centre, Dessau, Germany.
出版信息
Psoriasis (Auckl). 2015 Nov 2;5:125-128. doi: 10.2147/PTT.S54089. eCollection 2015.
INTRODUCTION
Psoriasis has long been considered a systemic inflammatory disease. Lately, it has been strongly associated with obesity, as well as other components of metabolic syndrome, such as dyslipidemia, insulin resistance, and arterial hypertension.
METHODS
We reviewed the literature of the last decade by using the keywords: psoriasis, metabolic syndrome, and/or obesity in PubMed and Medline.
RESULTS
Obesity and psoriasis seem to share similar profiles of systemic inflammation. Serum cytokines such as TNF-α, CRP, IL-6, and IL-12 are elevated in both disorders. The more severely an individual is affected with psoriasis, the more likely it is to be obese. This makes the disease an important health care issue, which requires the cooperation of dermatologists with other medical specialists.
DISCUSSION
This review attempts to summarize the links and risks that associate psoriasis with obesity, and highlight the concerns and queries for both disorders in the future.
引言
银屑病长期以来一直被视为一种全身性炎症性疾病。最近，它与肥胖以及代谢综合征的其他组成部分，如血脂异常、胰岛素抵抗和动脉高血压，有着密切关联。
方法
我们通过在PubMed和Medline中使用关键词“银屑病”“代谢综合征”和/或“肥胖”，回顾了过去十年的文献。
结果
肥胖和银屑病似乎具有相似的全身性炎症特征。在这两种病症中，血清细胞因子如肿瘤坏死因子-α、C反应蛋白、白细胞介素-6和白细胞介素-12都会升高。个体患银屑病越严重，就越有可能肥胖。这使得该疾病成为一个重要的医疗保健问题，需要皮肤科医生与其他医学专家合作。
讨论
本综述试图总结银屑病与肥胖之间的联系和风险，并突出未来对这两种病症的关注和疑问。
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