Zhang Z, Jia Y, Chen Y, Wang L, Lv X, Yang F, He Y, Ning Z, Qu L
Department of Animal Genetics and Breeding, National Engineering Laboratory for Animal Breeding, College of Animal Science and Technology, China Agricultural University, Beijing, China.
Institute of Animal Science, Chinese Academy of Agricultural Sciences, Beijing, China.
Anim Genet. 2018 Apr;49(2):132-136. doi: 10.1111/age.12639. Epub 2018 Feb 1.
It is well known that both British and American Pekin ducks originated from China. However, the populations differ substantially in production performance, but the genetic changes involved are still poorly understood. Herein, we sequenced 24 individual Pekin ducks (eight from each population) with an average sequencing depth of more than 45× for each population (mean coverage of 6.29 per individual). Among these populations from three different countries, we identified a large number of SNPs and indels as well as many unique population variants, which can be used as population-specific molecular markers. Genomic comparisons among the three duck populations revealed many candidate genes as well as pathways and Gene Ontology categories that are putatively associated with meat yield in the British population, growth in the American population and brain development in all three populations. These findings will enable a better understanding of the artificial selection history of Pekin ducks and provide a valuable resource for future research on the breeding of this species.
众所周知，英国北京鸭和美国北京鸭均起源于中国。然而，这两个种群在生产性能上存在显著差异，但其中涉及的基因变化仍知之甚少。在此，我们对24只北京鸭个体（每个种群8只）进行了测序，每个种群的平均测序深度超过45倍（每个个体的平均覆盖度为6.29）。在来自三个不同国家的这些种群中，我们鉴定出了大量单核苷酸多态性（SNP）和插入缺失（indel）以及许多独特的种群变异，这些变异可作为种群特异性分子标记。对这三个鸭种群的基因组比较揭示了许多候选基因以及可能与英国种群的肉产量、美国种群的生长以及所有三个种群的大脑发育相关的途径和基因本体论类别。这些发现将有助于更好地理解北京鸭的人工选择历史，并为该物种未来的育种研究提供宝贵资源。
