China National Center for Bioinformation, Beijing 100101, China.
National Genomics Data Center, Beijing Institute of Genomics, Chinese Academy of Sciences, Beijing 100101, China.
Nucleic Acids Res. 2021 Jan 8;49(D1):D1186-D1191. doi: 10.1093/nar/gkaa1005.
The Genome Variation Map (GVM; http://bigd.big.ac.cn/gvm/) is a public data repository of genome variations. It aims to collect and integrate genome variations for a wide range of species, accepts submissions of different variation types from all over the world and provides free open access to all publicly available data in support of worldwide research activities. Compared with the previous version, particularly, a total of 22 species, 115 projects, 55 935 samples, 463 429 609 variants, 66 220 associations and 56 submissions (as of 7 September 2020) were newly added in the current version of GVM. In the current release, GVM houses a total of ∼960 million variants from 41 species, including 13 animals, 25 plants and 3 viruses. Moreover, it incorporates 64 819 individual genotypes and 260 393 manually curated high-quality genotype-to-phenotype associations. Since its inception, GVM has archived genomic variation data of 43 754 samples submitted by worldwide users and served >1 million data download requests. Collectively, as a core resource in the National Genomics Data Center, GVM provides valuable genome variations for a diversity of species and thus plays an important role in both functional genomics studies and molecular breeding.
基因组变异图谱 (GVM; http://bigd.big.ac.cn/gvm/) 是一个公开的基因组变异数据存储库。它旨在收集和整合广泛物种的基因组变异，接受来自世界各地的不同变异类型的提交，并免费提供所有公开数据，以支持全球范围内的研究活动。与前一版本相比，特别是在当前版本中，共新增了 22 个物种、115 个项目、55935 个样本、463429609 个变异、66220 个关联和 56 个提交（截至 2020 年 9 月 7 日）。在当前版本的 GVM 中，共收录了来自 41 个物种的约 9.6 亿个变异，包括 13 种动物、25 种植物和 3 种病毒。此外，它还整合了 64819 个个体基因型和 260393 个手动整理的高质量基因型-表型关联。自成立以来，GVM 已经存储了来自全球用户提交的 43754 个样本的基因组变异数据，服务了超过 100 万次的数据下载请求。作为国家基因组学数据中心的核心资源之一，GVM 为多种物种提供了有价值的基因组变异，因此在功能基因组学研究和分子育种中都发挥着重要作用。
