He Zhimei, Xiao Yan, Zhang Jian-Rong, Zhang Penghui, Zhu Jun-Jie
State Key Laboratory of Analytical Chemistry for Life Science, School of Chemistry and Chemical Engineering Nanjing University, Nanjing 210023, China.
Chem Commun (Camb). 2018 Mar 25;54(24):2962-2965. doi: 10.1039/c7cc09532e. Epub 2018 Feb 1.
A cancer cell-specific, endogenous H/HO-activated, and O self-sufficient nanocomposite is engineered and characterized. Such NPs, with good biocompatibility and rapid response to intracellular H/HO, have demonstrated improved therapeutic effects in targeted cancer cells and activated MR signals in vitro, providing a promising strategy for effective PDT against tumor hypoxia.
一种癌细胞特异性、内源性H₂O₂激活且O₂自给自足的纳米复合材料被设计并表征。这类纳米颗粒具有良好的生物相容性且对细胞内H₂O₂反应迅速，已在体外显示出对靶向癌细胞有改善的治疗效果并激活了磁共振信号，为针对肿瘤缺氧的有效光动力疗法提供了一种有前景的策略。
