Zhou Y, Zheng Y, Li C, Hu J, Zhou Y, Geng L, Tao M
a Department of Gynecology and Obstetrics , Shanghai Jiao Tong University Affiliated Sixth People's Hospital , Shanghai , People's Republic of China.
Climacteric. 2018 Apr;21(2):179-183. doi: 10.1080/13697137.2018.1428295. Epub 2018 Feb 2.
To explore the correlation of body composition with the severity of menopausal symptoms, as well as each classic menopausal symptom.
A total of 758 (peri-)menopausal women were recruited (aged from 40 to 67 years) from the Menopause Clinic in the Shanghai Sixth People's Hospital. Different regions of fat mass, lean mass and fat-free mass were measured by bioelectrical impedance analysis, while menopausal symptoms were evaluated by valid modified Kupperman's index (KMI) in the Chinese version.
After adjusting for potential confounders, logistic regression revealed that trunk lean mass (odds ratio 0.29, 95% confidence interval 0.09-0.99) was the independent determinant of moderate to severe menopausal symptoms (KMI ≥ 16). In multiple regression analysis, significant relationships were found between body mass index and hot flushes/sweating and diabetes (p < 0.05). There was a significant relationship between lean mass and muscle/joint pain and sexual problems (p < 0.05). We also observed significant relationships between fat mass and hot flushes/sweating and muscle/joint pain.
Our findings indicated that trunk lean mass was an independent protective factor for moderate to severe menopausal symptoms. Strengthening the trunk lean mass may alleviate menopausal symptoms.
探讨身体成分与绝经症状严重程度以及各典型绝经症状之间的相关性。
从上海第六人民医院更年期门诊招募了758名年龄在40至67岁之间的（围）绝经女性。通过生物电阻抗分析测量脂肪量、瘦体重和去脂体重的不同区域，同时采用中文版改良Kupperman指数（KMI）对绝经症状进行评估。
在对潜在混杂因素进行校正后，逻辑回归显示躯干瘦体重（比值比0.29，95%置信区间0.09 - 0.99）是中度至重度绝经症状（KMI≥16）的独立决定因素。在多元回归分析中，发现体重指数与潮热/出汗及糖尿病之间存在显著关系（p<0.05）。瘦体重与肌肉/关节疼痛及性问题之间存在显著关系（p<0.05）。我们还观察到脂肪量与潮热/出汗及肌肉/关节疼痛之间存在显著关系。
我们的研究结果表明，躯干瘦体重是中度至重度绝经症状的独立保护因素。增加躯干瘦体重可能会缓解绝经症状。
