Woods Rosanne, Hess Rebecca, Biddington Carol, Federico Marc
Department of Exercise Science and Sport Studies, California University of Pennsylvania, 50 University Ave, California, PA 15419 USA.
Womens Midlife Health. 2020 Sep 15;6:10. doi: 10.1186/s40695-020-00058-9. eCollection 2020.
The purpose of this study was to examine the association of lean body mass (LBM) to the development of vasomotor symptoms (VMS) as women transition through menopause.
This study is a secondary use of data available for public use from follow up visits six through 10 for participants in the Study of Women's Health Across the Nation. The study examined 2533 women, between the ages 42-52 years, each year over a10-year period. Data was modeled for associations of lean body mass and VMS. Changes in LBM since prior visit and since baseline were also modeled along with differences in means using binary logistic regression, adjusting for covariates.
LBM was significantly associated to concurrent VMS ( = .036), percent change in LBM since prior visit ( = .003), percent change since baseline ( < .001), and overall means associations ( = .023). LBM was not significant for VMS at individual visit measures. In mixed regression modeling, time was significant ( < .0001) at all visits. The estimated probability of developing VMS decreases significantly as LBM increases.
Lean body mass is negatively associated with incident VMS. Our data suggests that maintaining higher levels of LBM during the menopausal transition may be protective against the development of VMS. Every woman will experience menopause in her life and the ability to potentially prevent the onset of specific symptoms through basic interventions, such as resistance training to increase lean body mass, may positively impact this large population.
本研究的目的是探讨女性在绝经过渡期间瘦体重（LBM）与血管舒缩症状（VMS）发生之间的关联。
本研究是对全国女性健康研究中参与者随访6至10次时可供公众使用的数据的二次分析。该研究在10年期间每年对2533名年龄在42 - 52岁之间的女性进行调查。对瘦体重与血管舒缩症状的关联进行数据建模。还对自上次访视以来和自基线以来瘦体重的变化以及使用二元逻辑回归分析的均值差异进行建模，并对协变量进行调整。
瘦体重与同时出现的血管舒缩症状显著相关（P = 0.036），自上次访视以来瘦体重的百分比变化（P = 0.003），自基线以来的百分比变化（P < 0.001）以及总体均值关联（P = 0.023）。在个体访视测量中，瘦体重对血管舒缩症状不显著。在混合回归模型中，时间在所有访视中均显著（P < 0.0001）。随着瘦体重增加，发生血管舒缩症状的估计概率显著降低。
瘦体重与血管舒缩症状的发生呈负相关。我们的数据表明，在绝经过渡期间维持较高水平的瘦体重可能对血管舒缩症状的发生具有保护作用。每个女性在其一生中都会经历绝经，通过基本干预措施（如进行抗阻训练以增加瘦体重）潜在预防特定症状发作的能力，可能会对这一庞大人群产生积极影响。
