Liu Weimin, Dong Zhiyong, Hu Ruixiang, Wang Cunchuan
1 Department of Gastrointestinal Surgery, The First Affiliated Hospital of Jinan University, Guangzhou, China.
Technol Cancer Res Treat. 2018 Jan 1;17:1533034617753810. doi: 10.1177/1533034617753810.
The relationship between vascular endothelial growth factor gene polymorphism and gastric cancer risk and its development, prognosis, and survival are still being debated. This meta-analysis was performed to assess these relationships. The association reports were identified from PubMed, Embase, Cochrane Library, and CBM-disc (China Biological Medicine Database), and eligible studies were included and calculated using the meta-analysis method. VEGF+936C/T, VEGF+405 G>C, VEGF-460 T>C, VEGF-1498 T>C, and VEGF-2578 C>A gene polymorphisms were found to be unassociated with gastric cancer risk for the overall population in this meta-analysis, whereas the VEGF-634 G>C GG genotype was associated with gastric cancer risk in the overall population. Furthermore, VEGF-634 G>C C allele and the GG genotype were associated with gastric cancer risk in Caucasians, and VEGF+1612G/A gene polymorphism was associated with gastric cancer risk for the Asian population. VEGF+936C/T gene polymorphism was not associated with the stage of cancer, lymph node metastasis, Lauren classification, or survival of gastric cancer. However, VEGF+936C/T T allele and TT genotype were associated with the tumor size of gastric cancer. In conclusion, the VEGF-634 G>C GG genotype was associated with gastric cancer risk in the overall population with the VEGF-634 G>C C allele and GG genotype being associated with risk in Caucasians and VEGF+1612G/A in the Asian population.
血管内皮生长因子基因多态性与胃癌风险及其发生、发展、预后和生存之间的关系仍存在争议。本荟萃分析旨在评估这些关系。从PubMed、Embase、Cochrane图书馆和中国生物医学数据库（CBM-disc）中识别相关的关联报告，并纳入符合条件的研究，采用荟萃分析方法进行计算。在本荟萃分析中，发现VEGF+936C/T、VEGF+405 G>C、VEGF-460 T>C、VEGF-1498 T>C和VEGF-2578 C>A基因多态性与总体人群的胃癌风险无关，而VEGF-634 G>C的GG基因型与总体人群的胃癌风险相关。此外，VEGF-634 G>C的C等位基因和GG基因型与白种人的胃癌风险相关，VEGF+1612G/A基因多态性与亚洲人群的胃癌风险相关。VEGF+936C/T基因多态性与胃癌的分期、淋巴结转移、Lauren分类或生存无关。然而，VEGF+936C/T的T等位基因和TT基因型与胃癌的肿瘤大小相关。总之，VEGF-634 G>C的GG基因型与总体人群的胃癌风险相关，VEGF-634 G>C的C等位基因和GG基因型与白种人的风险相关，VEGF+1612G/A与亚洲人群的风险相关。
