Zhuang Meng, Peng Zhi, Wang Jian, Su Xiangqian
Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Department of Gastrointestinal Surgery IV, Peking University Cancer Hospital and Institute, Beijing 100142, China.
J BUON. 2017 May-Jun;22(3):714-724.
Vascular endothelial growth factor (VEGF) plays important roles in the process of tumor growth and metastasis. Although the association between VEGF polymorphisms and gastric cancer risk has been extensively studied, available results remain controversial. To derive a convincing estimation of the relationship, a meta-analysis containing 6 VEGF (+936C/T, -634G/C, -460T/C, +1612G/A, -2578C/A and -1154G/A) gene polymorphisms was performed.
We conducted a systematic search of PubMed and Chinese National Knowledge Infrastructure (CNKI) to select relevant articles. Nine available case-control studies with 2,281 gastric cancer cases and 2,820 healthy controls met the inclusion criteria. The odds ratio (OR) and 95% confidence interval (95% CI) were used to evaluate the strength of the association.
This meta-analysis indicated that the VEGF-634 G allele carrier represented a risk factor for gastric cancer (GG+GC vs CC: OR=1.23, 95% CI=1.02-1.49, p=0.03). The VEGF +1612G/A polymorphism was associated with risk of gastric cancer (G allele vs A allele: OR=0.62, 95% CI=0.49- 0.79, p<0.0001; GG+GA vs AA: OR=0.16, 95% CI=0.05-0.51, p=0.002 and GA+AA vs GG: OR=1.57, 95% CI=1.21-2.04, p=0.008). For polymorphisms of VEGF +936C/T, -460C/T, -2578C/A , -1154G/A, no association was found with gastric cancer risk.
Our meta-analysis suggests that VEGF-634 G allele carrier may increase gastric cancer risk, whereas the VEGF +1612 G/A G allele and G allele carrier may decrease the risk. No association between+936C/T, -460C/T, -2578C/A, -1154G/A polymorphisms and susceptibility to gastric cancer was found.
血管内皮生长因子（VEGF）在肿瘤生长和转移过程中发挥重要作用。尽管VEGF基因多态性与胃癌风险之间的关联已得到广泛研究，但现有结果仍存在争议。为了对两者关系得出有说服力的评估，我们进行了一项包含6种VEGF（+936C/T、-634G/C、-460T/C、+1612G/A、-2578C/A和-1154G/A）基因多态性的荟萃分析。
我们对PubMed和中国知网（CNKI）进行了系统检索以选择相关文章。9项可用的病例对照研究，共2281例胃癌病例和2820例健康对照符合纳入标准。采用比值比（OR）和95%置信区间（95%CI）评估关联强度。
该荟萃分析表明，VEGF -634 G等位基因携带者是胃癌的一个危险因素（GG + GC vs CC：OR = 1.23，95%CI = 1.02 - 1.49，p = 0.03）。VEGF +1612G/A基因多态性与胃癌风险相关（G等位基因vs A等位基因：OR = 0.62，95%CI = 0.49 - 0.79，p < 0.0001；GG + GA vs AA：OR = 0.16，95%CI = 0.05 - 0.51，p = 0.002；GA + AA vs GG：OR = 1.57，95%CI = 1.21 - 2.04，p = 0.008）。对于VEGF +936C/T、-460C/T、-2578C/A、-1154G/A基因多态性，未发现与胃癌风险相关。
我们的荟萃分析表明，VEGF -634 G等位基因携带者可能增加胃癌风险，而VEGF +1612 G/A的G等位基因和G等位基因携带者可能降低风险。未发现+936C/T、-460C/T、-2578C/A、-1154G/A基因多态性与胃癌易感性之间存在关联。
