Sedaghat Mohamad-Reza, Askarizadeh Farshad, Nematy Mohsen, Narooie-Noori Foroozan, Heravian Javad, Rakhshandadi Tahereh, Rajabi Sattar
Cornea Research Center, Khatam-Al-Anbia Hospital, Mashhad University of Medical Sciences, Mashhad, Iran.
Department of Optometry, Refractive Errors Research Center, School of Paramedical Sciences, Mashhad University of Medical Sciences, Mashhad, Iran.
Med Hypothesis Discov Innov Ophthalmol. 2017 Fall;6(3):89-97.
This study aimed to assess the possible relationship of body mass index (BMI) and blood pressure (BP) with corneal biomechanical parameters in healthy subjects. The study included 88 eyes of 88 healthy subjects aged 20-40 years. After a thorough medical history, a digital sphygmomanometer was used to measure the systolic blood pressure (SBP) and diastolic blood pressure (DBP). In addition, several hematological and biochemical parameters were determined to assess general health. Prior the ophthalmic examination, the body height and weight were measured; then, the BMI was calculated. Finally, after comprehensive ophthalmic examination, all cases were evaluated with Pentacam (Oculus) in order to rule out corneal ectasia; then, the corneal biomechanical parameters of all individuals were measured using the Scheimpflug-based Corvis ST (Oculus Optikgeräte GmbH, Wetzlar, Germany). If the measurements of the hematological and biochemical parameters were within normal range, the results of the Corvis ST, BMI, and BP were included in the analysis carried out with SPSS software. The mean (± standard deviation [SD]) BMI, SBP, DBP, intraocular pressure (IOP), central corneal thickness (CCT), deformation amplitude, radius, and peak distance was 27.24 ± 4.80 kg/m2, 116.47 ± 11.21 mmHg, 80.51 ± 5.68 mmHg, 15.10 ± 1.70 mmHg, 533.10 ± 30.97 micrometer, 1.03 ± 0.11 mm, 7.51 ± 0.86 mm, and 5.03 ± 0.30 mm, respectively. Results showed no significant difference in IOP, CCT, peak distance, radius, and deformation amplitude between different BMI subcategories defined by World Health Organization (all P > 0.05). The results of the Corvis ST showed that corneal biomechanical parameters had no significant correlation with BMI, SBP, and DBP in three subgroups of BMI and all participants (all P > 0.05) but the results showed a positive correlation between CCT and IOP (P < 0.001, r = 0.504) in all participants. CCT and IOP had no correlation with BMI, SBP, and DBP (P > 0.05). This study showed that BMI and BP had no correlation with corneal biomechanical parameters in healthy subjects using the Corvis ST.
本研究旨在评估健康受试者的体重指数（BMI）和血压（BP）与角膜生物力学参数之间可能存在的关系。该研究纳入了88名年龄在20至40岁之间的健康受试者的88只眼睛。在详细询问病史后，使用数字血压计测量收缩压（SBP）和舒张压（DBP）。此外，还测定了多项血液学和生化参数以评估总体健康状况。在眼科检查前，测量身高和体重；然后计算BMI。最后，在进行全面的眼科检查后，使用Pentacam（Oculus）对所有病例进行评估以排除角膜扩张；随后，使用基于Scheimpflug原理的Corvis ST（德国韦茨拉尔Oculus Optikgeräte GmbH公司）测量所有个体的角膜生物力学参数。如果血液学和生化参数的测量值在正常范围内，则将Corvis ST、BMI和BP的结果纳入使用SPSS软件进行的分析。BMI、SBP、DBP、眼压（IOP）、中央角膜厚度（CCT）、变形幅度、半径和峰值距离的平均值（±标准差[SD]）分别为27.24±4.80kg/m²、116.47±11.21mmHg、80.51±5.68mmHg、15.10±1.70mmHg、533.10±30.97微米、1.03±0.11mm、7.51±0.86mm和5.03±0.30mm。结果显示，世界卫生组织定义的不同BMI亚组之间，IOP、CCT、峰值距离、半径和变形幅度均无显著差异（所有P>0.05）。Corvis ST的结果表明，在BMI的三个亚组和所有参与者中，角膜生物力学参数与BMI、SBP和DBP均无显著相关性（所有P>0.05），但结果显示所有参与者中CCT与IOP呈正相关（P<0.001，r=0.504）。CCT和IOP与BMI、SBP和DBP均无相关性（P>0.05）。本研究表明，在使用Corvis ST的健康受试者中，BMI和BP与角膜生物力学参数无相关性。
