KCa(H2O)2[Fe(CN)6]·H2O 纳米颗粒作为一种抗金黄色葡萄球菌的抗菌剂。
KCa(H O) [Fe (CN) ]⋅H O Nanoparticles as an Antimicrobial Agent against Staphylococcus aureus.
机构信息
Department of Chemistry and Biochemistry, Kent State University, Kent, OH, 44240, USA.
Department of Biological Sciences, Kent State University, Kent, OH, 44240, USA.
出版信息
Angew Chem Int Ed Engl. 2018 Feb 19;57(8):2214-2218. doi: 10.1002/anie.201713177. Epub 2018 Feb 2.
Abstract
Biocompatible nanoparticles based on a calcium analogue of Prussian blue were designed and synthesized to take advantage of their ability to penetrate the cell membrane in Staphylococcus aureus and to undergo selective ion exchange with intracellular iron to disrupt iron metabolism in such pathogenic bacteria for antibacterial applications. KCa(H O) [Fe (CN) ]⋅H O nanoparticles penetrate the bacterial cell membrane and sequester intracellular iron by ion exchange to form insoluble Prussian blue, thus inhibiting bacterial growth.
摘要
基于普鲁士蓝类似物的生物相容性纳米粒子被设计和合成，以利用其穿透金黄色葡萄球菌细胞膜的能力，并与细胞内铁进行选择性离子交换，从而破坏此类致病菌的铁代谢，用于抗菌应用。KCa(H2O) [Fe(CN)6]⋅H2O 纳米粒子通过离子交换穿透细菌细胞膜并螯合细胞内铁，形成不溶性普鲁士蓝，从而抑制细菌生长。
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