Intervirology. 2017;60(4):125-130. doi: 10.1159/000485898. Epub 2018 Jan 25.
Human papillomavirus (HPV) vaccination is currently not included in the national vaccination program in Iran. Regional data on the distribution of HPV types in women are important as they can predict the impact of currently available vaccines and help health policy makers to consider all the possibilities with regard to HPV vaccination.
A total of 1,218 Iranian women with normal cervical cytology were included in this study. The presence of the HPV genome was investigated in all specimens by PCR assay, and all HPV-positive samples were genotyped.
Totally, HPV was detected in 88 samples (7.2%). According to different geographical regions, the HPV prevalence varied: the highest HPV prevalence was observed in the North (11.7%) and the lowest in the Center (4.5%) of Iran, and this difference reached a statistically significant level (p < 0.05). In this study, the most frequent HPV types were HPV 16, 18, 66, and 11, representing 63.8% of all HPV infections.
Based on this study, it is estimated that HPV vaccines could have a great impact on the prevention of cervical cancer in Iran. This study highlights the necessity of introducing educational programs in high schools, robust screening programs, and vaccination in Iran.
人乳头瘤病毒（HPV）疫苗目前未被纳入伊朗国家免疫规划。了解 HPV 型别在女性中的分布情况对区域性数据非常重要，因为这可以预测现有疫苗的效果，并有助于卫生决策者考虑 HPV 疫苗接种的所有可能性。
本研究共纳入 1218 例宫颈细胞学正常的伊朗女性。采用 PCR 法检测所有标本中 HPV 基因组的存在情况，对所有 HPV 阳性样本进行基因分型。
共检出 88 例（7.2%）HPV 阳性样本。按照不同的地理区域，HPV 流行率存在差异：伊朗北部 HPV 流行率最高（11.7%），中部最低（4.5%），差异具有统计学意义（p < 0.05）。本研究中，最常见的 HPV 型别为 HPV 16、18、66 和 11，占所有 HPV 感染的 63.8%。
本研究表明，HPV 疫苗可能对伊朗宫颈癌的预防产生重大影响。本研究强调了在伊朗开展高中教育项目、建立强有力的筛查计划和推广疫苗接种的必要性。
