College of Life Science, Sichuan Agricultural University, Ya'an 625014, China.
Institute of Agro-Products Processing Science and Technology, Sichuan Academy of Agricultural Sciences, Chengdu 610066, China.
Int J Mol Sci. 2023 Jul 19;24(14):11615. doi: 10.3390/ijms241411615.
Camellia oil (CO) is a high medicinal and nutritional value edible oil. However, its ability to alleviate fat accumulation in high-fat has not been well elucidated. Therefore, this study aimed to investigate the effect of CO on fat accumulation in high-fat via transcriptome and metabolome analysis. The results showed that CO significantly reduced fat accumulation in high-fat by 10.34% (Oil Red O method) and 11.54% (TG content method), respectively. Furthermore, CO primarily altered the transcription levels of genes involved in longevity regulating pathway. Specifically, CO decreased lipid storage in high-fat by inhibiting fat synthesis. In addition, CO supplementation modulated the abundance of metabolic biomarkers related to pyrimidine metabolism and riboflavin metabolism. The integrated transcriptome and metabolome analyses indicated that CO supplementation could alleviate fat accumulation in high-fat by regulating retinol metabolism, drug metabolism-cytochrome P450, metabolism of xenobiotics by cytochrome P450, ascorbate and aldarate metabolism, and pentose and glucuronate interconversions. Overall, these findings highlight the potential health benefits of CO that could potentially be used as a functional edible oil.
油茶籽油（CO）是一种具有高药用和营养价值的食用油。然而，其缓解高脂肪饮食引起的脂肪积累的能力尚未得到充分阐明。因此，本研究旨在通过转录组和代谢组分析探讨 CO 对高脂肪饮食引起的脂肪积累的影响。结果表明，CO 分别通过油红 O 法和 TG 含量法使高脂肪饮食引起的脂肪积累减少了 10.34%和 11.54%。此外，CO 主要改变了参与长寿调节途径的基因的转录水平。具体来说，CO 通过抑制脂肪合成减少了高脂肪饮食中的脂肪储存。此外，CO 补充还调节了与嘧啶代谢和核黄素代谢相关的代谢生物标志物的丰度。转录组和代谢组的综合分析表明，CO 补充可通过调节视黄醇代谢、药物代谢-细胞色素 P450、细胞色素 P450 介导的外源物质代谢、抗坏血酸和醛酸代谢以及戊糖和葡萄糖醛酸转化来缓解高脂肪饮食引起的脂肪积累。总的来说，这些发现强调了 CO 的潜在健康益处，它可能被用作功能性食用油。
