[5-氟脱氧尿苷刺激的耐辐射DNA合成的可能诱导性质]
[Possible inducible nature of radioresistant DNA synthesis stimulated by 5-fluorodeoxyuridine].
作者信息
Synzynys B I, Brozmanova E, Saenko A S
出版信息
Radiobiologiia. 1986 Mar-Apr;26(2):221-3.
PMID:2939488
Abstract
A study was made of the effect of cycloheximide on the radioresistant DNA synthesis stimulated by preincubation of cells with 5-fluorodeoxyuridine (FdUrd). It was shown that after the cycloheximide treatment the radioresistant DNA synthesis was absent while in FdUrd-treated cells it did occur. It is assumed that the FdUrd-stimulated radioresistant DNA synthesis is of an inducible nature.
摘要
研究了环己酰亚胺对细胞经5-氟脱氧尿苷（FdUrd）预孵育刺激后的抗辐射DNA合成的影响。结果表明，经环己酰亚胺处理后，抗辐射DNA合成消失，而在FdUrd处理的细胞中确实发生了抗辐射DNA合成。据推测，FdUrd刺激的抗辐射DNA合成具有诱导性质。
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