[5-氟脱氧尿苷诱导DNA的抗辐射合成并使HeLa细胞对γ辐射敏感]
[5-fluorodeoxyuridine induces radioresistant synthesis of DNA and sensitizes HeLa cells to gamma radiation].
作者信息
Synzynys B I, Brozmanova E, Gotlib V Ia, Saenko A S
出版信息
Radiobiologiia. 1985 Sep-Oct;25(5):593-7.
PMID:2933760
Abstract
It was shown that preincubation of HeLa cells with 5-fluorodeoxyuridine (10(-6) M) induced DNA synthesis resistant to gamma-radiation (6 Gy). At the same time, the death rate of exposed cells increased and nucleoid relaxation decreased. The role of DNA synthesis inhibitors in the reproductive death of exposed cells is discussed.
摘要
结果表明，用5-氟脱氧尿苷（10⁻⁶ M）对HeLa细胞进行预孵育可诱导产生对γ射线（6 Gy）抗性的DNA合成。同时，受照射细胞的死亡率增加，核质松弛减少。文中讨论了DNA合成抑制剂在受照射细胞生殖死亡中的作用。
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Radiobiologiia. 1985 Sep-Oct;25(5):593-7.
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