社区环境、睡眠质量与认知能力下降：居住地和睡眠质量是否重要？
Neighborhoods, sleep quality, and cognitive decline: Does where you live and how well you sleep matter?
机构信息
Department of Social Sciences and Health Policy, Wake Forest School of Medicine, Winston-Salem, NC, USA.
Department of Internal Medicine, Section on Geriatrics and Gerontology, Wake Forest School of Medicine, Winston-Salem, NC, USA.
出版信息
Alzheimers Dement. 2018 Apr;14(4):454-461. doi: 10.1016/j.jalz.2017.10.007. Epub 2018 Feb 1.
INTRODUCTION
We evaluated the association between neighborhood socioeconomic status (NSES) and sleep quality on cognitive decline in the Health and Retirement Study.
METHODS
Health and Retirement Study participants (n = 8090), aged 65+ with DNA and multiple biennial cognitive observations (abbreviated Telephone Interview for Cognitive Status), were included. Participants were grouped into quartiles of NSES and sleep quality scores. We adjusted for apolipoprotein E ε4, demographic, and cardiovascular risk factors. Random effects modeling evaluated cognitive change over time.
RESULTS
NSES and sleep were significantly associated with cognitive decline, and there was a significant interaction between them (P = .02). Significant differences between high/low NSES and high/low sleep quality (P < .0001) were found.
DISCUSSION
Sleep and NSES were associated with cognitive decline; the association between sleep and cognition appeared stronger among those with low NSES. The association between low NSES, poor sleep quality, and cognitive decline was roughly equivalent to the association between apolipoprotein E ε4 and cognitive decline.
简介
我们评估了邻里社会经济地位（NSES）与健康与退休研究中认知能力下降之间的关系。
方法
纳入了健康与退休研究的参与者（n=8090），年龄在 65 岁及以上，有 DNA 和多次两年一次的认知观察（简称电话认知状态测试）。参与者被分为 NSES 和睡眠质量评分的四分位数组。我们调整了载脂蛋白 E ε4、人口统计学和心血管危险因素。随机效应模型评估了随时间的认知变化。
结果
NSES 和睡眠与认知能力下降显著相关，且两者之间存在显著的交互作用（P=0.02）。高/低 NSES 和高/低睡眠质量之间存在显著差异（P<0.0001）。
讨论
睡眠和 NSES 与认知能力下降有关；在 NSES 较低的人群中，睡眠与认知之间的关系似乎更强。低 NSES、睡眠质量差和认知能力下降之间的关联大致相当于载脂蛋白 E ε4 与认知能力下降之间的关联。
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