补骨脂素加紫外线A诱导的水疱：5例报告

Blisters Induced by PUVA: A Report of 5 Cases.

作者信息

Vázquez-Osorio I, González-Delgado S, Suárez-García C, Gonzalvo-Rodríguez P, Rodríguez-Díaz E

机构信息

Servicio de Dermatología, Hospital Universitario de Cabueñes, Gijón, Asturias, España.

出版信息

Actas Dermosifiliogr (Engl Ed). 2018 Oct;109(8):e11-e16. doi: 10.1016/j.ad.2017.10.011.

DOI:10.1016/j.ad.2017.10.011

PMID:29397873

Abstract

Blisters associated with PUVA treatments are an adverse effect of photochemotherapy that has been reported in the literature. Asymptomatic blisters appear spontaneously mainly on the lower limbs and resolve without treatment. The differential diagnoses to consider include a phototoxic reaction, pseudoporphyria, and PUVA-induced bullous pemphigoid. We describe the clinical and histologic features in 5 cases of blistering secondary to PUVA treatment. If this adverse effect is accurately diagnosed, photochemotherapy need not be interrupted, and unnecessary diagnostic procedures and additional treatments can be avoided.

摘要

与补骨脂素紫外线A（PUVA）治疗相关的水疱是光化学疗法的一种不良反应，已有文献报道。无症状水疱主要自发出现于下肢，无需治疗即可消退。需要考虑的鉴别诊断包括光毒性反应、假性卟啉病和PUVA诱导的大疱性类天疱疮。我们描述了5例PUVA治疗继发水疱的临床和组织学特征。如果能准确诊断这种不良反应，就无需中断光化学疗法，还可避免不必要的诊断程序和额外治疗。