Department of Molecular, Cellular and Biomedical Sciences, Sophie Davis School of Biomedical Education, City University of New York School of Medicine, NY, USA.
Biochem Pharmacol. 2018 Mar;149:205-223. doi: 10.1016/j.bcp.2018.01.042. Epub 2018 Feb 14.
Nitric oxide (NO) a gaseous free radical is one of the ten smallest molecules found in nature, while hydrogen sulfide (HS) is a gas that bears the pungent smell of rotten eggs. Both are toxic yet they are gasotransmitters of physiological relevance. There appears to be an uncanny resemblance between the general actions of these two gasotransmitters in health and disease. The role of NO and HS in cancer has been quite perplexing, as both tumor promotion and inflammatory activities as well as anti-tumor and antiinflammatory properties have been described. These paradoxes have been explained for both gasotransmitters in terms of each having a dual or biphasic effect that is dependent on the local flux of each gas. In this review/commentary, I have discussed the major roles of NO and HS in carcinogenesis, evaluating their dual nature, focusing on the enzymes that contribute to this paradox and evaluate the pros and cons of inhibiting or inducing each of these enzymes.
一氧化氮（NO）是一种气态自由基，是自然界中发现的最小分子之一，而硫化氢（HS）是一种具有臭鸡蛋气味的气体。两者都有毒，但都是具有生理相关性的气体递质。这两种气体递质在健康和疾病中的一般作用似乎有惊人的相似之处。NO 和 HS 在癌症中的作用一直令人费解，因为已经描述了它们在肿瘤促进和炎症活动以及抗肿瘤和抗炎特性中的作用。这两种气体递质的这些悖论可以根据它们各自具有的双相或双相效应来解释，该效应取决于每种气体的局部通量。在这篇综述/评论中，我讨论了 NO 和 HS 在致癌作用中的主要作用，评估了它们的双重性质，重点讨论了导致这种悖论的酶，并评估了抑制或诱导这两种酶中的每一种的利弊。
