Department of Modern Sciences and Technologies, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran; These authors contributed equally to this work.
Institute of Materials Physics and Engineering, Department of Applied Science and Technology (DISAT), Politecnico di Torino, Torino, Italy; These authors contributed equally to this work.
Trends Biotechnol. 2018 Apr;36(4):430-444. doi: 10.1016/j.tibtech.2017.12.003.
The biggest strategic challenge for tissue engineering is the development of efficient vascularized networks in engineered tissues and organs. Bioactive glasses (BGs) are potent biomaterials for inducing angiogenesis in hard and soft tissue engineering applications. Because tissue-healing processes strongly depend on angiogenesis, recent interest in BGs has increased dramatically. BGs with improved angiogenetic properties can be developed by adding a range of metallic ions (e.g., Cu, Co) into their structure, but further development of BGs with improved angiogenic activity is required, and many crucial questions remain to be answered. We introduce here the salient features, the hurdles that must be overcome, and the hopes and constraints for the development of this approach.
组织工程面临的最大战略挑战是在工程组织和器官中开发有效的血管化网络。生物活性玻璃（BGs）是在硬组织和软组织工程应用中诱导血管生成的有效生物材料。由于组织修复过程强烈依赖于血管生成，因此人们对 BGs 的兴趣大大增加。通过在 BGs 的结构中添加一系列金属离子（例如 Cu、Co）可以开发出具有改善的血管生成特性的 BGs，但是需要进一步开发具有改善的血管生成活性的 BGs，并且仍有许多关键问题需要解答。在这里，我们介绍了这种方法的显著特点、必须克服的障碍、以及发展这种方法的希望和限制。
