Department of Neuroscience, The Rappaport Faculty of Medicine and Research Institute, Technion-Israel Institute of Technology, 1 Efron Street, Haifa 31096, Israel.
Department of Neuroscience, The Rappaport Faculty of Medicine and Research Institute, Technion-Israel Institute of Technology, 1 Efron Street, Haifa 31096, Israel.
Trends Neurosci. 2018 Mar;41(3):124-127. doi: 10.1016/j.tins.2018.01.006. Epub 2018 Feb 1.
Two recent papers have tackled the fundamental questions of how place fields are formed in a new environment and what plasticity mechanisms contribute to this process. Bittner et al., in their recent publication, discovered a novel plasticity rule that, in contrast to previous rules, spans the behavioral, seconds-long, timescale. Sheffield et al. have monitored, for the first time, dendritic activity during place field formation, and show the emergence of spatially tuned local NMDA spikes in basal dendrites of CA1 neurons. Together, these papers suggest that multiple complementary dendritic plasticity mechanisms may contribute to place field formation in changing environmental contexts.
最近的两篇论文探讨了在新环境中如何形成位置场以及哪些可塑性机制有助于这一过程的基本问题。Bittner 等人在他们最近的出版物中发现了一个新的可塑性规则，与以前的规则不同，这个规则跨越了行为、持续数秒的时间尺度。Sheffield 等人首次监测了位置场形成过程中的树突活动，并显示 CA1 神经元基底树突中出现了空间调谐的局部 NMDA 尖峰。这两篇论文共同表明，多种互补的树突可塑性机制可能有助于在不断变化的环境背景下形成位置场。
