通过流式细胞术评估前体B淋巴细胞白血病微小残留病分析的新标志物
Evaluating New Markers for Minimal Residual Disease Analysis by Flow Cytometry in Precursor B Lymphoblastic Leukemia.
作者信息
Jain Sonal, Mehta Anurag, Kapoor Gauri, Bhurani Dinesh, Jain Sandeep, Agrawal Narendra, Ahmed Rayaz, Kumar Dushyant
机构信息
1Department of Pathology and Laboratory Services, Rajiv Gandhi Cancer Institute and Research Centre, Sector - 5, Rohini, New Delhi, 110085 India.
3Department of Pediatric Hematology and Oncology, Rajiv Gandhi Cancer Institute and Research Centre, Sector - 5, Rohini, New Delhi, 110085 India.
出版信息
Indian J Hematol Blood Transfus. 2018 Jan;34(1):48-53. doi: 10.1007/s12288-017-0845-5. Epub 2017 Jul 3.
Abstract
Minimal residual disease is currently the most powerful prognostic indicator in Precursor B lymphoblastic leukemia. Multiparameter flow cytometry is the most commonly used modality. Seventy three B ALL cases and 15 normal marrows were evaluated for expression patterns of leukemia markers (CD38, CD58, CD73) in all 73 cases and CD66c, CD86 and CD123 in 23 cases. CD73 was aberrantly expressed in 90.41% cases and CD86 in 60.87% B ALL cases. Thus addition of these markers in MRD panels can increase the sensitivity of the assay.
摘要
微小残留病目前是前体B淋巴细胞白血病中最有力的预后指标。多参数流式细胞术是最常用的检测方法。对73例B淋巴细胞白血病病例和15例正常骨髓进行评估，检测所有73例病例中白血病标志物（CD38、CD58、CD73）的表达模式，以及23例病例中CD66c、CD86和CD123的表达模式。90.41%的病例中CD73异常表达，60.87%的B淋巴细胞白血病病例中CD86异常表达。因此，在微小残留病检测组合中加入这些标志物可提高检测的敏感性。
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