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CD146 在小儿 B 细胞急性淋巴细胞白血病中的上调及其对治疗结果的影响。

Upregulation of CD146 in Pediatric B-Cell Acute Lymphocytic Leukemia and Its Implications on Treatment Outcomes.

机构信息

Clinical Pathology Department, South Egypt Cancer Institute, Assiut University, Assiut, Egypt.

Medical Microbiology & Immunology Department, Faculty of Medicine, Assiut University, Assiut, Egypt.

出版信息

J Immunol Res. 2020 Feb 8;2020:9736159. doi: 10.1155/2020/9736159. eCollection 2020.

DOI:10.1155/2020/9736159
PMID:32090132
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7031726/
Abstract

UNLABELLED

. We studied through flow cytometry the expression of CD146 on different T cells, and B-cell ALL blasts trying to correlate its expression with different prognostic factors of B-cell ALL and treatment outcomes. . All pediatric patients with B-cell ALL were subjected to bone marrow examination and cytochemistry, flow cytometric immunophenotyping using monoclonal antibodies utilized for diagnosis of B-ALL including CD34, CD19, CD10, CD22, and intracellular IgM. The diagnosis was based on standard morphologic, cytochemical, and immunophenotypic followed by flow cytometric detection of CD146 expression on blast cells, CD4, and CD8 T cells.

RESULTS

Significant accumulations of CD146CD4 cells, CD146CD8 cells, CD4, CD8, and lymphocytes in patients were compared to controls, the mean percentages of CD146CD4 cells, CD146CD8 cells, and CD146 blasts were significantly higher in patients than controls, and in addition, these cells were associated with poor overall survival and disease-free survival. The median OS for patients with complete response was 22 ± 1.633 (95%CI = 18.799-25.201), while for those without complete response, it was 13 ± 3.928 (95%CI = 5.301-25.699), with log-rank = 5.71, = 0.017.

CONCLUSION

CD146 was expressed significantly in children's B-ALL and associated with poor prognostic features including poor response and treatment outcomes and could be a possible poor prognostic factor in pediatric B-cell ALL.

摘要

未标注

。我们通过流式细胞术研究了不同 T 细胞和 B 细胞急性淋巴细胞白血病（B-ALL）blasts 中 CD146 的表达情况，并试图将其表达与 B-ALL 的不同预后因素和治疗结果相关联。所有儿童 B-ALL 患者均接受骨髓检查和细胞化学检查、流式细胞术免疫表型分析，采用诊断 B-ALL 的单克隆抗体，包括 CD34、CD19、CD10、CD22 和细胞内 IgM。诊断基于标准形态学、细胞化学和免疫表型，随后通过流式细胞术检测 blast 细胞、CD4 和 CD8 T 细胞上 CD146 的表达。

结果

与对照组相比，患者中 CD146CD4 细胞、CD146CD8 细胞、CD4、CD8 和淋巴细胞的显著累积，患者中 CD146CD4 细胞、CD146CD8 细胞和 CD146blasts 的平均百分比明显高于对照组，此外，这些细胞与总体生存率和无病生存率降低相关。完全缓解患者的中位 OS 为 22 ± 1.633（95%CI = 18.799-25.201），而未完全缓解患者的中位 OS 为 13 ± 3.928（95%CI = 5.301-25.699），对数秩= 5.71，= 0.017。

结论

CD146 在儿童 B-ALL 中表达显著，与预后不良特征相关，包括不良反应和治疗结果，可能是儿童 B 细胞 ALL 的一个潜在不良预后因素。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f7ec/7031726/7081a5b0cc8e/JIR2020-9736159.011.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f7ec/7031726/0a5deee986a4/JIR2020-9736159.006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f7ec/7031726/4b0228cd1586/JIR2020-9736159.007.jpg
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