Laboratory for Integrative Neuroscience , National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health , Rockville , Maryland 20852 , United States.
ACS Chem Neurosci. 2018 Sep 19;9(9):2146-2161. doi: 10.1021/acschemneuro.7b00508. Epub 2018 Feb 19.
The endocannabinoid (eCB) signaling system plays a key role in short-term and long-term synaptic plasticity in brain regions involved in various neural functions ranging from action selection to appetite control. This review will explore the role of eCBs in shaping neural circuit function to regulate behaviors. In particular, we will discuss the behavioral consequences of eCB mediated long-term synaptic plasticity in different brain regions. This review brings together evidence from in vitro and ex vivo studies and points out the need for more in vivo studies.
内源性大麻素 (eCB) 信号系统在涉及从动作选择到食欲控制等各种神经功能的大脑区域的短期和长期突触可塑性中发挥着关键作用。本综述将探讨 eCB 调节行为的方式在塑造神经回路功能中的作用。特别是，我们将讨论不同脑区中 eCB 介导的长时程突触可塑性的行为后果。本综述汇集了来自体外和离体研究的证据，并指出需要进行更多的体内研究。
