Lahat N, Aghai E, Quitt M, Froom P
Diagn Immunol. 1986;4(2):75-80.
Autologous mixed lymphocyte reaction (AMLR) was measured in 12 patients with multiple myeloma. In ten patients depressed AMLR was found. Depletion of adherent monocytes caused enhancement of AMLR in those with a normal OKT4/OKT8 ratio. Only after monocyte depletion was a high correlation found between the AMLR values and the absolute number of OKT+4-T lymphocytes in the patients' peripheral blood. There was an inverse correlation between the suppressive effect of adherent monocytes on AMLR and the patients' serum levels of polyclonal IgG and IgM. Defects in both monocytes and OKT+4-T cells might have caused the low AMLR values and perhaps played a role in multiple myeloma immunodeficiency.
对12例多发性骨髓瘤患者进行了自体混合淋巴细胞反应（AMLR）检测。10例患者的AMLR降低。去除贴壁单核细胞后，OKT4/OKT8比值正常的患者其AMLR增强。仅在单核细胞去除后，才发现患者外周血中AMLR值与OKT + 4 - T淋巴细胞绝对数之间存在高度相关性。贴壁单核细胞对AMLR的抑制作用与患者血清多克隆IgG和IgM水平呈负相关。单核细胞和OKT + 4 - T细胞的缺陷可能导致了低AMLR值，并且可能在多发性骨髓瘤免疫缺陷中起作用。
