Butters N, Wolfe J, Granholm E, Martone M
Cortex. 1986 Mar;22(1):11-32. doi: 10.1016/s0010-9452(86)80030-2.
Two investigations concerned with the memory deficits of patients with Huntington's Disease (HD) were performed. In the first experiment, early and advanced HD patients showed superior recognition memory than did alcoholic Korsakoff patients on modified recall and recognition forms of the Rey Auditory Verbal Learning Test. In contrast, on a letter fluency test (FAS) requiring the patients to search their semantic memories, both HD groups produced fewer correct words and perseveration errors than did the alcoholic Korsakoff group. In the second experiment, HD patients and Korsakoff patients were compared in their and recognition of short passages. While the HD and Korsakoff patients were equally impaired on recall tests, the HD patients evidenced significantly better recognition memory than did the amnesic group. As on the fluency test, the prose of the Korsakoff patients was characterized by intrusion (i.e., perseverative) errors. The results of the two experiments indicate that HD and Korsakoff patients' memory deficits are related to deficiencies in retrieval and an increased sensitivity to proactive interference, respectively.
进行了两项关于亨廷顿舞蹈症（HD）患者记忆缺陷的调查。在第一个实验中，早期和晚期HD患者在改良版的雷伊听觉词语学习测试的回忆和识别形式上，表现出比酒精性柯萨科夫综合征患者更好的识别记忆。相比之下，在一项要求患者搜索语义记忆的字母流畅性测试（FAS）中，两个HD组产生的正确单词和持续性错误都比酒精性柯萨科夫组少。在第二个实验中，对HD患者和柯萨科夫患者在短文回忆和识别方面进行了比较。虽然HD患者和柯萨科夫患者在回忆测试中的受损程度相同，但HD患者的识别记忆明显优于失忆组。与流畅性测试一样，柯萨科夫患者的短文存在插入（即持续性）错误。两项实验的结果表明，HD患者和柯萨科夫患者的记忆缺陷分别与提取缺陷和对前摄干扰的敏感性增加有关。
