Martone M, Butters N, Payne M, Becker J T, Sax D S
Arch Neurol. 1984 Sep;41(9):965-70. doi: 10.1001/archneur.1984.04050200071020.
Patients with Huntington's disease (HD), patients with alcoholic Korsakoff's syndrome, and normal control subjects were compared on tests of skill learning (mirror reading) and verbal recognition. Like previously reported results, the patients with Korsakoff's syndrome acquired the mirror-reading skill at a normal rate but were severely impaired in their recognition of the words used on the mirror-reading task. In contrast to the amnesic patients, the demented patients with HD were retarded in their ability to acquire this skill but showed normal verbal recognition. Besides emphasizing substantial differences in the anterograde substantial differences in the anterograde memory disorders of these two patient populations, the results suggest that the memory disorder of patients with HD may appear much more severe when recall rather than recognition test paradigms are employed. This failure of recall by the patients with HD may be due to an inability to generate strategies necessary to search their short- and long-term memories.
对患有亨廷顿舞蹈症（HD）的患者、患有酒精性柯萨科夫综合征的患者以及正常对照受试者进行了技能学习测试（镜像阅读）和言语识别测试。与先前报道的结果一样，患有柯萨科夫综合征的患者以正常速度习得镜像阅读技能，但在识别镜像阅读任务中使用的单词方面严重受损。与失忆症患者不同，患有HD的痴呆患者获得该技能的能力迟缓，但言语识别正常。除了强调这两类患者群体在顺行性记忆障碍方面的实质性差异外，结果还表明，当采用回忆而非识别测试范式时，HD患者的记忆障碍可能显得更为严重。HD患者的这种回忆失败可能是由于无法生成搜索其短期和长期记忆所需的策略。
