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CRISPR Screens Uncover Genes that Regulate Target Cell Sensitivity to the Morphogen Sonic Hedgehog.CRISPR筛选揭示调控靶细胞对形态发生素音猬因子敏感性的基因。
Dev Cell. 2018 Jan 22;44(2):271. doi: 10.1016/j.devcel.2018.01.002.
2
Noggin and Sonic hedgehog are involved in compensatory changes within the motoneuron-depleted mouse spinal cord.诺金和刺猬信号通路参与了运动神经元缺失的小鼠脊髓中的代偿性变化。
J Neurol Sci. 2013 Sep 15;332(1-2):102-9. doi: 10.1016/j.jns.2013.06.029. Epub 2013 Jul 13.
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LRP2, an auxiliary receptor that controls sonic hedgehog signaling in development and disease.LRP2,一种在发育和疾病中控制音猬因子信号传导的辅助受体。
Dev Dyn. 2016 May;245(5):569-79. doi: 10.1002/dvdy.24394. Epub 2016 Mar 4.
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Hedgehog signaling pathway as a potential target in the treatment of advanced gastric cancer.刺猬信号通路作为晚期胃癌治疗的潜在靶点。
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Enhanced production of neuroprogenitors, dopaminergic neurons, and identification of target genes by overexpression of sonic hedgehog in human embryonic stem cells.通过在人胚胎干细胞中过表达 sonic hedgehog 增强神经前体细胞、多巴胺能神经元的生成,并鉴定靶基因。
Stem Cells Dev. 2012 Mar 20;21(5):729-41. doi: 10.1089/scd.2011.0134. Epub 2011 Aug 8.
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The morphogen Sonic hedgehog is an indirect angiogenic agent upregulating two families of angiogenic growth factors.形态发生素音猬因子是一种间接血管生成因子,可上调两个血管生成生长因子家族。
Nat Med. 2001 Jun;7(6):706-11. doi: 10.1038/89083.
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The morphogen sonic hedgehog collaborates with netrin-1 to guide axons in the spinal cord.形态发生素音猬因子与netrin-1协同作用,引导脊髓中的轴突。
Trends Neurosci. 2003 Dec;26(12):641-3. doi: 10.1016/j.tins.2003.09.006.
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Hedgehog signalling is required for maintenance of myf5 and myoD expression and timely terminal differentiation in zebrafish adaxial myogenesis.在斑马鱼近轴肌生成过程中,刺猬信号通路对于维持myf5和myoD的表达以及及时的终末分化是必需的。
Dev Biol. 2001 Aug 1;236(1):136-50. doi: 10.1006/dbio.2001.0193.
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Morphogen to mitogen: the multiple roles of hedgehog signalling in vertebrate neural development.形态发生素到有丝分裂原:刺猬信号通路在脊椎动物神经发育中的多重作用
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Expression of Sonic hedgehog and retinal opsin genes in experimentally-induced myopic chick eyes.音猬因子和视网膜视蛋白基因在实验性诱导的近视雏鸡眼中的表达
Exp Eye Res. 2000 Nov;71(5):459-67. doi: 10.1006/exer.2000.0898.

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Direct ionic stress sensing and mitigation by the transcription factor NFAT5.转录因子NFAT5对离子应激的直接感知与缓解
Sci Adv. 2025 Feb 21;11(8):eadu3194. doi: 10.1126/sciadv.adu3194. Epub 2025 Feb 19.
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Applying Spinal Cord Organoids as a quantitative approach to study the mammalian Hedgehog pathway.应用脊髓类器官作为一种定量方法来研究哺乳动物 Hedgehog 通路。
PLoS One. 2024 Jun 25;19(6):e0301670. doi: 10.1371/journal.pone.0301670. eCollection 2024.
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P4HA2 hydroxylates SUFU to regulate the paracrine Hedgehog signaling and promote B-cell lymphoma progression.P4HA2 羟化 SUFU 以调节旁分泌 Hedgehog 信号通路并促进 B 细胞淋巴瘤的进展。
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Direct ionic stress sensing and mitigation by the transcription factor NFAT5.转录因子NFAT5对离子应激的直接感知与缓解
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Genome-wide screen reveals Rab12 GTPase as a critical activator of Parkinson's disease-linked LRRK2 kinase.全基因组筛选揭示Rab12 GTP酶是帕金森病相关LRRK2激酶的关键激活因子。
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Arih2 regulates Hedgehog signaling through smoothened ubiquitylation and ER-associated degradation.Arih2 通过 Smoothened 泛素化和内质网相关降解调节 Hedgehog 信号通路。
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The Pseudo-Natural Product Rhonin Targets RHOGDI.罗宁假天然产物靶向 RHOGDI。
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Mosmo Is Required for Zebrafish Craniofacial Formation.斑马鱼颅面形成需要Mosmo。
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An updated SYSCILIA gold standard (SCGSv2) of known ciliary genes, revealing the vast progress that has been made in the cilia research field.一个经过更新的 SYSCILIA 金标准(SCGSv2),其中包含已知的纤毛基因,揭示了在纤毛研究领域取得的巨大进展。
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The conserved MASRPF motif in the Attractin homolog, Distracted, is required for association with Drosophila E3-ligase Mgrn1.吸引素同源物“注意力分散”中保守的MASRPF基序是与果蝇E3连接酶Mgrn1结合所必需的。
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本文引用的文献

1
Centriole triplet microtubules are required for stable centriole formation and inheritance in human cells.中心体三联微管对于人类细胞中稳定的中心体形成和遗传是必需的。
Elife. 2017 Sep 14;6:e29061. doi: 10.7554/eLife.29061.

CRISPR Screens Uncover Genes that Regulate Target Cell Sensitivity to the Morphogen Sonic Hedgehog.

作者信息

Pusapati Ganesh V, Kong Jennifer H, Patel Bhaven B, Krishnan Arunkumar, Sagner Andreas, Kinnebrew Maia, Briscoe James, Aravind L, Rohatgi Rajat

出版信息

Dev Cell. 2018 Jan 22;44(2):271. doi: 10.1016/j.devcel.2018.01.002.

DOI:10.1016/j.devcel.2018.01.002
PMID:29401421
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5804815/
Abstract
摘要