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用于多种癌症治疗联合递送与联合疗法的聚合物基纳米载体

Polymer-Based Nanocarriers for Co-Delivery and Combination of Diverse Therapies against Cancers.

作者信息

Yan Guowen, Li Aihua, Zhang Aitang, Sun Yong, Liu Jingquan

机构信息

School of Materials Science and Engineering, Qingdao University, No. 308 Ningxia Road, Qingdao 266071, China.

School of Pharmacy, Qingdao University, No. 38 Dengzhou Road, Qingdao 266021, China.

出版信息

Nanomaterials (Basel). 2018 Feb 3;8(2):85. doi: 10.3390/nano8020085.

Abstract

Cancer gives rise to an enormous number of deaths worldwide nowadays. Therefore, it is in urgent need to develop new therapies, among which combined therapies including photothermal therapy (PTT) and chemotherapy (CHT) using polymer-based nanocarriers have attracted enormous interest due to the significantly enhanced efficacy and great progress has been made so far. The preparation of such nanocarriers is a comprehensive task involving the cooperation of nanomaterial science and biomedicine science. In this review, we try to introduce and analyze the structure, preparation and synergistic therapeutic effect of various polymer-based nanocarriers composed of anti-tumor drugs, nano-sized photothermal materials and other possible parts. Our effort may bring benefit to future exploration and potential applications of similar nanocarriers.

摘要

如今,癌症在全球范围内导致了大量死亡。因此,迫切需要开发新的治疗方法,其中包括使用基于聚合物的纳米载体的光热疗法(PTT)和化疗(CHT)的联合疗法,由于其显著提高的疗效,迄今为止已经取得了巨大进展并引起了广泛关注。制备此类纳米载体是一项涉及纳米材料科学和生物医学科学合作的综合性任务。在这篇综述中,我们试图介绍和分析由抗肿瘤药物、纳米级光热材料和其他可能部分组成的各种基于聚合物的纳米载体的结构、制备方法和协同治疗效果。我们的努力可能会为未来类似纳米载体的探索和潜在应用带来益处。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e933/5853717/f8e670b910d6/nanomaterials-08-00085-sch001.jpg

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