Li S Y, Nelson D S
Int J Immunopharmacol. 1986;8(2):213-9. doi: 10.1016/0192-0561(86)90061-5.
Mice were treated with cyclosporin A (CsA) (25-100 mg/kg daily, by mouth) during the induction of autoantibodies to erythrocytes by means of injections of rat erythrocytes. A high dose of CsA inhibited autoantibody production whereas a low dose temporarily potentiated it. Cell transfer and anti-Thy 1.2 treatment indicated the presence of suppressor T cells in the spleens of immunized mice. Their formation was inhibited by treatment with high dose CsA and potentiated by low dose CsA. In the CBA/H mice used, CsA treatment after immunization had no effect on autoantibody titres.
在通过注射大鼠红细胞诱导抗红细胞自身抗体的过程中，给小鼠口服环孢素A（CsA）（每日25 - 100毫克/千克）。高剂量的CsA抑制自身抗体产生，而低剂量则暂时增强自身抗体产生。细胞转移和抗Thy 1.2治疗表明免疫小鼠脾脏中存在抑制性T细胞。高剂量CsA处理可抑制它们的形成，低剂量CsA则增强其形成。在所使用的CBA/H小鼠中，免疫后进行CsA处理对自身抗体滴度没有影响。
