Cox K O, Allison A C, Samcewicz B
Clin Immunol Immunopathol. 1983 Jul;28(1):90-5. doi: 10.1016/0090-1229(83)90191-5.
Mice injected with rat erythrocytes produce erythrocyte autoantibodies and suppressor cells that inhibit autoantibody production without inhibiting the net production of antibodies against rat RBC. Here it is shown that injecting mice with Cyclosporin-A daily for up to 13 days during the course of injections of rat RBC significantly inhibits autoantibody production. Antibody production against rat RBC was also inhibited. The Cyclosporin-A-treated mice that did not produce autoantibodies produced suppressor cells that inhibited autoantibody production in adoptive transfer experiments. These suppressor cells, which did not inhibit antibody production against rat RBC, were destroyed by treatment with anti-Thy 1.2 serum and complement. From the results, it is suggested that in this experimentally induced autoimmune disease, suppressor T cells may be activated and/or preferentially spared in Cyclosporin-A-treated mice.
注射大鼠红细胞的小鼠会产生红细胞自身抗体和抑制细胞，这些抑制细胞可抑制自身抗体的产生，而不抑制针对大鼠红细胞的抗体的净产生。本文表明，在注射大鼠红细胞的过程中，每天给小鼠注射环孢素A，持续13天，可显著抑制自身抗体的产生。针对大鼠红细胞的抗体产生也受到抑制。在过继转移实验中，未产生自身抗体的经环孢素A处理的小鼠产生了抑制自身抗体产生的抑制细胞。这些不抑制针对大鼠红细胞的抗体产生的抑制细胞，在用抗Thy 1.2血清和补体处理后被破坏。从结果来看，提示在这种实验性诱导的自身免疫性疾病中，抑制性T细胞可能在经环孢素A处理的小鼠中被激活和/或优先得以保留。
