Cramer Steven C
Departments of Neurology, Anatomy & Neurobiology and Physical Medicine & Rehabilitation, University of California, Irvine, CA, USA.
J Stroke. 2018 Jan;20(1):57-70. doi: 10.5853/jos.2017.02796. Epub 2018 Jan 31.
Stroke remains a major cause of human disability worldwide. In parallel with advances in acute stroke interventions, new therapies are under development that target restorative processes. Such therapies have a treatment time window measured in days, weeks, or longer and so have the advantage that they may be accessible by a majority of patients. Several categories of restorative therapy have been studied and are reviewed herein, including drugs, growth factors, monoclonal antibodies, activity-related therapies including telerehabilitation, and a host of devices such as those related to brain stimulation or robotics. Many patients with stroke do not receive acute stroke therapies or receive them and do not derive benefit, often surviving for years thereafter. Therapies based on neural repair hold the promise of providing additional treatment options to a majority of patients with stroke.
中风仍然是全球人类残疾的主要原因。随着急性中风干预措施的进展，针对恢复过程的新疗法正在研发中。此类疗法的治疗时间窗以数天、数周或更长时间来衡量，因此具有多数患者都可采用的优势。几类恢复性疗法已得到研究，本文将对其进行综述，包括药物、生长因子、单克隆抗体、包括远程康复在内的与活动相关的疗法，以及一系列诸如与脑刺激或机器人技术相关的设备。许多中风患者未接受急性中风治疗，或接受了治疗但未从中获益，此后往往存活数年。基于神经修复的疗法有望为大多数中风患者提供更多治疗选择
