Sultan Sadia, Zaheer Hasan Abbas, Waheed Usman, Baig Mohammad Amjad, Rehan Asma, Irfan Syed Mohammed
Department of Hematology and Blood Bank, Liaquat National Hospital and Medical College, Karachi, Pakistan.
Safe Blood Transfusion Programme, Ministry of National Health Services, Government of Pakistan, Islamabad, Pakistan.
J Lab Physicians. 2018 Jan-Mar;10(1):64-67. doi: 10.4103/JLP.JLP_97_17.
Internal quality control (IQC) is the backbone of quality assurance program. In blood banking, the quality control of blood products ensures the timely availability of a blood component of high quality with maximum efficacy and minimal risk to potential recipients. The main objective of this study is to analyze the IQC of blood products as an indicator of our blood bank performance.
An observational cross-sectional study was conducted at the blood bank of Liaquat National Hospital and Medical College, from January 2014 to December 2015. A total of 100 units of each blood components were arbitrarily chosen during the study. Packed red cell units were evaluated for hematocrit (HCT); random platelet concentrates were evaluated for pH, yield, and culture; fresh frozen plasma (FFP) and cryoprecipitate (CP) were evaluated for unit volume, factor VIII, and fibrinogen concentrations.
A total of 400 units were tested for IQC. The mean HCT of packed red cells was 69.5 ± 7.24, and in 98% units, it met the standard (<80% of HCT). The mean platelet yield was 8.8 ± 3.40 × 10/L and pH was ≥6.2 in 98% bags; cultures were negative in 97% of units tested. Mean factor VIII and fibrinogen levels were found to be 84.24 ± 15.01 and 247.17 ± 49.69 for FFP, respectively. For CP, mean factor VIII and fibrinogen level were found to be 178.75 ± 86.30 and 420.7 ± 75.32, respectively.
The IQC of blood products at our blood bank is in overall compliance and met recommended international standards. Implementation of standard operating procedures, accomplishment of standard guidelines, proper documentation with regular audit, and staff competencies can improve the quality performance of the transfusion services.
内部质量控制（IQC）是质量保证计划的核心。在血液库中，血液制品的质量控制可确保及时提供高质量的血液成分，使其功效最大化，并将对潜在受血者的风险降至最低。本研究的主要目的是分析血液制品的内部质量控制情况，以此作为我们血液库工作表现的一个指标。
于2014年1月至2015年12月在利亚卡特国家医院和医学院血液库进行了一项观察性横断面研究。在研究期间，每种血液成分随机选取100单位。对浓缩红细胞单位进行血细胞比容（HCT）评估；对随机血小板浓缩物进行pH值、产量和培养评估；对新鲜冰冻血浆（FFP）和冷沉淀（CP）进行单位体积、凝血因子VIII和纤维蛋白原浓度评估。
共对400单位进行了内部质量控制检测。浓缩红细胞的平均血细胞比容为69.5±7.24，98%的单位符合标准（血细胞比容<80%）。血小板平均产量为8.8±3.40×10/L，98%的袋子中pH值≥6.2；97%检测的单位培养结果为阴性。FFP的凝血因子VIII和纤维蛋白原平均水平分别为84.24±15.01和247.17±49.69。对于CP，凝血因子VIII和纤维蛋白原平均水平分别为178.75±86.30和420.7±75.32。
我们血液库血液制品的内部质量控制总体符合要求，并达到了推荐的国际标准。实施标准操作程序、完成标准指南、通过定期审核进行妥善记录以及提高工作人员能力，可改善输血服务的质量表现。
